Journal: Journal of Pharmacy Research

Article Id: JPRS-GS-00001913
Title: Influence of 60-day introduction of tartrazine in various concentrations on the ultrastructure of tibia graft biomineral
Category: General Sciences
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    Aim: The aim of the research was to study the effect of 60-day intake of tartrazine with food at various concentrations on the ultrastructure of the biomineral crystalline lattice of the tibia regenerates among sexually mature white rats. Material and Method: The experiment was carried out on 140 rats distributed into four groups: 1st group - control, 2nd- the rats with an applied 2.0 mm defect in both tibia, and the group 3, 4 - the rats with tartrazine administered intragastrically for 60 days in the dose of 750 and 1500 mg/kg/day, after which the defect for the tibia was applied. X-ray structural study was carried out using DRON-2.0 apparatus with a goniometric attachment GUR-5. Кαa radiation of copper with the wavelength of 0.1542 nM was used; the voltage and the strength of the anode current were 30 kV and 20 A, respectively. Results and Discussion: The results of the study showed that the microtexturing ratio of the regenerate biomineral was less than the 2nd group values at 3rd, 10th, 15th, 24th, and 45th day after the administration of tartrazine at the dose of 750 mg/kg/day by 3.49%, 6.24%, 6.50%, 8.19%, and 6.33%, and the sizes of crystallites were more by 14.14%, 8.40%, and 3.45% on 15th, 24th, and 45th day. With the dose increase of preliminary introduced tartrazine up to 1500 mg/kg/day, the regeneration biomineral development slowed more significantly: The microtexturing coefficient was less than the values of the 4th group in all terms by 4.49%, 7.36%, 7.95%, 8.53%, and 7.55% and crystallite sizes increased by 5.30%, 20.36%, 11.47%, and 9.16% during 10–45th day. Conclusion: Thus, intragastric administration of tartrazine for 60 days is accompanied by the delay in the development of the biomineral crystalline lattice of bone regenerate, and the intensity of the changes depends on tartrazine dose.

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  • About the authors and Affiliations

    Author(s) Name:

    Vladyslav V. Luzin1, Olga N. Fastova1, Aleksei V. Tverskoi2, Vitaliy N. Morozov2*, Elena N. Morozova2

    Affiliation(s) Name:

    1Department of Anthropotomy, State Institution “Lugansk State Medical University” 91045, People’s Republic of Lugansk, 50-Letya Oborony Luganska qr. 1g, Russia,
    2Department of General Medicine and Paediatrics, Faculty of General Medicine and Paediatrics of Medical Institute, Belgorod State National Research University, Belgorod 308015, Russia.

    *Corresponding author: Vitaliy N. Morozov, Department of Human Anatomy, Faculty of General Medicine and  Paediatrics of Medical Institute, Belgorod State National Research University, 85 Pobedy Street, Belgorod 308015, Russia.

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    Author:

    Vladyslav V. Luzin1, Olga N. Fastova1, Aleksei V. Tverskoi2, Vitaliy N. Morozov2*, Elena N. Morozova2

    Title:Influence of 60-day introduction of tartrazine in various concentrations on the ultrastructure of tibia graft biomineral
    Journal:Journal of Pharmacy Research
    Vol(issue):11 (December )
    Year:2017
    Page No: (1531-1534)
  • Experimental Methods Keywords

    Methodology:Regeneration, X-ray diffraction analysis
    Research Materials:Bone biomineral,Tartrazine

Keywords

Bone biomineral Rats Regeneration Tartrazine X-ray diffraction analysis

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