Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001916
Title: Comparative cytotoxic studies of methanolic, ethyl acetate, chloroform, and pet ether (60–80°C) extracts by MTT assay of marine sponge Haliclona taenurimosa
Category: Pharmacology
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  • Abstract

    Cytotoxic study of marine sponge Haliclona taenurimosa With 79% of the earth’s surface covered by water research into thechemistry of marine organisms is relatively unexplored and represents a vast resource for new medicines to combat majordisease such as cancer, AIDS, or malaria. Standard research involves extraction of the organism in a suitable solvent followed by assay of this crude extract for a particular disease target. In this study, we have collected the marine sponge Haliclona taenurimosa from Vizhinjam coast, identified and undergone successive solvent extraction by different solvents of increasing polarity. The color and consistency of the extract noted. MTT assay was performed on SW480 (Colon carcinoma) cell line,and pet ether (60–80°) extract showed significant result with LD50 value 21.9747 µg/ml.

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    Author(s) Name:

    S. Rani*, V. Padmaja

    Affiliation(s) Name:

    Department of Pharmacognosy, College of Pharmaceutical Sciences, Medical College, Thiruvananthapuram, Kerala, India


    *Corresponding author: S. Rani, College of Pharmaceutical Sciences, Medical College, Thiruvananthapuram, Kerala, India.

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    Author:

    S. Rani*, V. Padmaja

    Title:Comparative cytotoxic studies of methanolic, ethyl acetate, chloroform, and pet ether (60–80°C) extracts by MTT assay of marine sponge Haliclona taenurimosa
    Journal:Journal of Pharmacy Research
    Vol(issue):11(12)
    Year:2017
    Page No: (0-0)
  • Experimental Methods Keywords

    Methodology:Optical density, LD50, MTT assay
    Research Materials:marine sponge Haliclona taenurimosa

Keywords

Optical density LD50 MTT assay Marine sponge

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