Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001923
Title: Phytochemical screening and in vitro antioxidant activities of ethanolic gel extract of Aloe adigratana Reynolds
Category: Pharmacology
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    Objective: Aloe adigratana Reynolds is an herb that belongs to the Xanthorrhoeaceae family. It is native species to Tigray region in Northern Ethiopia and locally known as ere, it is called the healing plant because of its wound and burn healing properties. The present study was carried out to perform the phytochemical screening with different organic solvents and evaluate the in vitro antioxidant activities of ethanolic extract of A. adigratana Reynolds gel. Methods: The present study was to assess the qualitative phytochemical analysis and in vitro antioxidants potential of ethanolic extract of A. adigratana Reynolds gel by 1,1-diphenyl-2-picrylhydrazyl, reducing power assay, hydroxyl radical, nitric oxide, and superoxide radical scavenging activities using standard methods. Results: Qualitative phytochemical screening revealed that ethanolic extract of A. adigratana Reynolds gel contained a maximum number of secondary metabolites such as flavonoids, tannins and phenolic compounds, and terpenoid then other solvent extracts; further, the in vitro antioxidant activity of A. adigratana Reynolds ethanolic gel extract showed significant superoxide radical and nitric oxide scavenging activity with 76.67% and 65.39% inhibition with half maximal inhibitory concentration = 36.94 µg/ml and 62.35 µg/ml, respectively. Conclusion: It can be concluded that ethanolic extract of A. adigratana Reynolds gel had significant antioxidant properties, due to the presence of polyphenolic compounds, and could serve as a potential source of natural antioxidants, for the development of therapeutic antioxidant drugs.

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    Author(s) Name:

    G. Hadera brhane1, V. K. Gopalakrishnan1, Zenebe Hagos1, Mulugeta Hiruy2, K. Devaki3, K. Krishna Chaithanya1*

    Affiliation(s) Name:

    1Department of Chemistry, College of Natural and Computational Sciences, Aksum University, Axum, Ethiopia,
    2Department of Biochemistry, College of Health Sciences, Referral Campus, Aksum University, Axum, Ethiopia,
    3Department of Biochemistry and Bioinformatics, Karpagam University, Coimbatore, Tamil Nadu, India

    *Corresponding author: Dr. Krishna Chaithanya Karri, Department of Chemistry, College of Natural and Computational Sciences, Aksum University, Axum, Tigray Region, Ethiopia

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    Author:

    G. Hadera brhane1, V. K. Gopalakrishnan1, Zenebe Hagos1, Mulugeta Hiruy2, K. Devaki3, K. Krishna Chaithanya1*

    Title:Phytochemical screening and in vitro antioxidant activities of ethanolic gel extract of Aloe adigratana Reynolds
    Journal:Journal of Pharmacy Research
    Vol(issue):12 (January)
    Year:2018
    Page No: (13-19)
  • Experimental Methods Keywords

    Methodology:Antioxidant activity
    Research Materials:Aloe adigratana

Keywords

Phytochemical Aloe adigratana Reynolds gel Antioxidants 1 1-diphenyl-2-picrylhydrazyl

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