Journal: Journal of Pharmacy Research

Article Id: JPRS-MB-00001930
Title: Detection of inducible clindamycin resistance among clinical isolates of Staphylococcus aureus
Category: Microbiology
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    Introduction and Background: The resistance to antibiotic employed against staphylococcal isolates is an alarming problem. This has led to the interest in using macrolid-lincosamide streptogramin B (MLSB) antibiotics to treat infection produce by Staphylococcus aureus. In vitro test for detecting clindamycin suspectibility may fail to detect inducible clindamycin resistance due to presence of erm gene which results in treatment failure. Aim: This study aims to develop a simple method for detection of inducible resistance to clindamycin in staphylococcal isolates exhibiting resistance to erythromycin. Methodology: A total of 20 clinical isolates of S. aureus were subjected to antibiotics suspectibility testing by disc diffusion method. Inducible resistance to clindamycin was detected by D-test as per CLSI guideline. Result: 20% isolates of were positive for iMLB phenotype, while 15% isolates were belong to MS phenotypes.

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    Author(s) Name:

    S. Rani*, V. Padmaja

    Affiliation(s) Name:

    Department of Pharmacognosy, College of Pharmaceutical Sciences, Medical College, Thiruvananthapuram, Kerala, India

    *Corresponding author: S. Rani, College of Pharmaceutical Sciences, Medical College, Thiruvananthapuram, Kerala, India.

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    Author:

    S. Rani*, V. Padmaja

    Title:Detection of inducible clindamycin resistance among clinical isolates of Staphylococcus aureus
    Journal:Journal of Pharmacy Research
    Vol(issue):11(12)
    Year:2017
    Page No: (1539-1542)
  • Experimental Methods Keywords

    Methodology:20 clinical isolates, disc diffusion method,clindamycin, D-test as per CLSI guideline
    Research Materials:Clindamycin

Keywords

Clindamycin resistance Constitutive macrolide-lincosamide-streptogramin Inducible macrolide- lincosamide-streptogramin B phenotype Methicillin-resistant Staphylococcus aureus Multiple sclero

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