Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001932
Title: Organ distribution of potential hypoglycemic drugs С7070
Category: Pharmacology
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Introduction: The organ distribution of a potential hypoglycemic drug - C7070 in rats was studied. Materials and Methods: The object of the study was the pharmacological substance C7070. The C7070 concentration was determined by high-performance liquid chromatography with mass spectrometer (MS)/MS detection. The measurement range was from 0.02 μg to 3876.00 μg in 1 ml of plasma or 1 g. Chromatographic separation was carried out on a 150 mm × 3.0 mm column of Zorbax Eclipse XDB C18 with a particle size of 3.0 μm (Agilent technology, USA). To obtain stable results for all analytical cycles, a protective membrane of Zorbax Eclipse XDB C18 (Agilent Technologies, USA) measuring 12.5 mm × 3.0 mm with a particle size of 5.0 μm at 40°C was used. Ballast proteins in test solutions were precipitated with acetonitrile, followed by extraction of the analyte with ultrasound. Results and Discussions: The drug is well distributed into organs. The greatest content of C7070 was observed in the tissues of the small intestine. The smallest content of C7070 was observed in muscle tissue and brain. The parameters obtained can be useful for clinical application and further studies of preparations C7070 on its basis.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    Alexander L. Kulikov*, Mikhail V. Pokrovskii, Tatyana V. Avtina, Olga A. Osipova, Sergey B. Nikolaev, Olga A. Efremova, Viktor A. Ruzhenkov

    Affiliation(s) Name:

    Department of Pharmacology, Medical University of NRU BelSU, Belgorod, Russia

    *Corresponding author: Alexander L. Kulikov, Department of Pharmacology, Medical University of NRU BelSU 85, Pobedy Street, Belgorod - 308015, Russia

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Alexander L. Kulikov*, Mikhail V. Pokrovskii, Tatyana V. Avtina, Olga A. Osipova, Sergey B. Nikolaev, Olga A. Efremova, Viktor A. Ruzhenkov

    Title:Organ distribution of potential hypoglycemic drugs С7070
    Journal:Journal of Pharmacy Research
    Vol(issue):11 (December )
    Year:2017
    Page No: (1547-1551)
  • Experimental Methods Keywords

    Methodology:high-performance liquid chromatography with mass spectrometer (MS)/MS detection
    Research Materials:hypoglycemic drugs С7070

Keywords

C7070 Diabetes High-performance liquid chromatography Hypoglycemic agents Organ distribution Rat blood plasma

Our Services

Most Downloaded List