Journal: Drug Invention Today

Article Id: JPRS-PS-00001939
Title: Cardiac mechanisms of chronic heart failure development in patients with ischemic heart disease, postman arcticcardiosclerosis of the elderly
Category: Pharmacological Screening
Section: Research Article
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    Aim: The objective of this study was to study the formation of myocardial remodeling in elderly patients with CHF of ischemic genesis. Materials and Methods: The object of our study was 140 elderly men suffering from CHF with a history of myocardial infarction more than 4 months ago; the average age of the examined persons was 68.4 ± 7.8 years. Results: It was determined that hypertrophic remodeling develops in most elderly patients with IHD, postinfarction cardiosclerosis, and a smaller number of patients have dilated myocardial remodeling. Thus, the morphometric study of myocardial tissue
    in patients with eccentric hypertrophy of the LV revealed a significant reduction in the size of the cardiomyocyte nuclei (94.08 ± 16.41, P = 0.0057) in comparison with patients with concentric hypertrophy with a group without signs of remodeling and control group. Conclusion: It was established that structural changes occur in the formation of postinfarction cardiosclerosis. Morphological studies revealed an increase in size and a decrease in the number of myocytes and an increase in the connective tissue matrix. The density of the myocardium increases accompanied by a diastolic LV disturbance.

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    Author(s) Name:

    Olga A. Osipova1, Nina I. Zhernakova1, Alfiya E. Pushkareva2, Oksana N. Belousova1

    Affiliation(s) Name:


    1Department of Pharmacology, Belgorod State National Research University, 85, Pobedy Street, Belgorod 308015, Russia,
    2Department of Hospital Therapy, Bashkir State Medical University, Ufa 450000, Republic of Bashkortostan, Ufa, LeninaStreet, 3, Russia

    *Corresponding author: Olga A. Osipova, Department of Pharmacology, Belgorod State National Research University, 85,Pobedy Street, Belgorod 308015, Russia.

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    Author:

    Olga A. Osipova1, Nina I. Zhernakova1, Alfiya E. Pushkareva2, Oksana N. Belousova1

    Title:Cardiac mechanisms of chronic heart failure development in patients with ischemic heart disease, postman arcticcardiosclerosis of the elderly
    Journal:Drug Invention Today
    Vol(issue):9 (December)
    Year:2017
    Page No: (39-43)
  • Experimental Methods Keywords

    Methodology:Articcardiosclerosis, Ischemic heart disease
    Research Materials:Acute myocardial infarction

Keywords

Acute myocardial infarction Articcardiosclerosis Ischemic heart disease

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