Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001965
Title: Antidiabetic activity of methonolic extract of Operculina turpethum (l.) Silva manso stem in streptozotocin induced diabetic rats
Category: Pharmacology
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    Diabetes mellitus (DM) consists of a group of syndromes characterized by hyperglycemia. the prevalence of both type 1 and type 2 DM is increasing worldwide, the prevalence of type 2 is rising much more rapidly because of increasing obesity and reduced activity levels as counties become more industrialized. The antidiabetic potential of the methanolic extract of Operculina turpethum stem (MEOTS) (Convolvulaceae), a medicinal plant widely used in the traditional Ayurveda and Siddha systems of medicine for the treatment of diabetes mellitus was evaluated in the Streptozotocin (STZ) - induced type 2 diabetic models. The doses of 50 mg/kg and 100 mg/kg of MEOTS were administered to normal, glucose loaded and experimental diabetic rats for 21 days. Significant (p< 0.05) reduction in fasting blood glucose levels were observed in the normal rats at 3hr as well as in the treated diabetic animals at 21 days Significant results were observed in the estimated parameters, thereby justifying the use of the plant in the indigenous system of medicine.

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    Author(s) Name:

    Shankaraiah Pulipaka1*, Challa Srinivas Reddy 2 , Ravindra Babu. P3 , SampathKumar.Ch1

    Affiliation(s) Name:

    1Trinity College of Pharmaceutical Sciences, Peddapally, Karimnagar, A.P, India, 505 172

    2Vaagdevi College of Pharmacy, Ramnagar, Hanmakonda, Warangal, A.P India, 506001

    3KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, A. P, India, 520 010

    *Corresponding author.
    Shankaraiah Pulipaka
    Trinity College of Pharmaceutical Sciences,
    Peddapally,
    Karimnagar, A.P, Pin: 505 172,India

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    Author:

    Shankaraiah Pulipaka1*, Challa Srinivas Reddy 2 , Ravindra Babu. P3 , SampathKumar.Ch1

    Title:Antidiabetic activity of methonolic extract of Operculina turpethum (l.) Silva manso stem in streptozotocin induced diabetic rats
    Journal:Journal of Pharmacy Research
    Vol(issue):4 (December)
    Year:2011
    Page No: (4593-4595)
  • Experimental Methods Keywords

    Methodology:Type 2 diabetes,Antidiabetic activity,STZ
    Research Materials:Operculina turpethum

Keywords

Type 2 diabetes STZ Operculina turpethum Glibenclamide

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