Journal: Drug Invention Today

Article Id: JPRS-D(DD)-00001968
Title: Substantiation of the technology for obtaining an extract from the fruit of blessed milk thistle for a geriatric drug creation
Category: Drug (Discovery/Development)
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    Aim: This paper presents the results of studying the effect of ethanol concentration in the water-ethanol mixture on the qualitative and quantitative composition of extracts obtained from crushed fruits of blessed milk thistle with high-performance liquid chromatography analysis. Materials and Method: For the extraction, plant materials were used: “Blessed milk thistle additive” made from grinded blessed milk thistle fruits by PJSC “Lektravy,” Zhitomir, Ukraine, date 28.03.17, series No. 002, shelf life 24 months. Result and Discussion: The optimal concentration of ethanol as an extractant was determined for the maximum extraction of phenolic compounds from plant raw materials. The effect of temperature on the extraction degree of extractives during the filtration extraction method was studied, and optimal parameters for the isolation of biologically active compounds from this plant material were proposed. Conclusion: It was found that the optimal concentration of ethanol in the water-ethanol mixture, which simultaneously extracts hydroxycinnamic acids, taxifolin, and flavonolignans and the fruits of blessed milk thistle, falls within the range of 64 ± 6% by weight.

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    Author(s) Name:

    Elena T. Zhilyakova1 , Oleg O. Novikov2 , Nikolay N. Boyko1 *, Dmitriy I. Pisarev2 , Zoya E. Tsvetkova1

    Affiliation(s) Name:

    1Department of Pharmaceutical Technology, Belgorod State University 85, Belgorod 308015, Russia,
    2Department of Pharmaceutical Chemistry and Pharmacognosy, Belgorod State University 85, Belgorod 308015, Russia

    *Corresponding author: Nikolay N. Boyko, Department of Pharmaceutical Technology, Belgorod State University 85, Pobedy St., Belgorod 308015, Russia

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    Author:

    Elena T. Zhilyakova1 , Oleg O. Novikov2 , Nikolay N. Boyko1 *, Dmitriy I. Pisarev2 , Zoya E. Tsvetkova1

    Title:Substantiation of the technology for obtaining an extract from the fruit of blessed milk thistle for a geriatric drug creation
    Journal:Drug Invention Today
    Vol(issue):9 (December)
    Year:2017
    Page No: (59-64)
  • Experimental Methods Keywords

    Methodology:Extraction,
    Research Materials:Milk thistle

Keywords

Blessed milk thistle fruits Geriatrics Water-ethanol extracts

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