Journal: Drug Invention Today

Article Id: JPRS-BSN-00001969
Title: Proteins P53 and B-cell lymphoma-2 in pathogenesis missed and spontaneous abortions
Category: Biomaterials ( Synthetic and Natural )
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    mRNA expression of p53, p21, B-cell lymphoma-2 (BCL-2), Bax, Noxa and MDM2 in decidual tissue (endometrium) of 50 patients with missed abortions, 47 patients with spontaneous abortions, and 57 patients with artificial abortion (control group) at 6–10 weeks of gestation were examined using reverse transcription quantitative polymerase chain reaction. Expression of 53 mRNA had no significant differences in patients with missed and spontaneous abortions. Significant increase of proapoptotic protein Noxa, accompanied with anti-apoptotic protein BCL-2 elevation was observed in the endometrium of patients with missed abortions. In patients with spontaneous abortions, only increase of Noxa has been observed. It can be suggested, that increase of BCL-2 in patients with missed abortions, when embryo resorption has happened, protects nearby embryos in case of multiple pregnancies. No significant changes of p21 mRNA were discovered in both groups, which indicates, that cell cycle arrest is not involved in the pathogenesis of early miscarriages. No significant changes of Bax and MDM2 mRNA expression were discovered in decidual tissue of patients with missed and spontaneous abortions.

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    Author(s) Name:

    Olga P. Lebedeva*, Irina O. Zhukova, Olesya N. Ivashova, Sergey P. Pakhomov, Mikhail I. Churnosov

    Affiliation(s) Name:

    Department of General Chemistry, Faculty of Biology and Chemistry, Belgorod State University, 308024, Pobedy Street, 85, Belgorod, Russia

    *Corresponding author: Olga P. Lebedeva, Faculty of Biology and Chemistry, Belgorod State University, 308024, Pobedy Street, 85, Belgorod, Russia.

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    Author:

    Olga P. Lebedeva*, Irina O. Zhukova, Olesya N. Ivashova, Sergey P. Pakhomov, Mikhail I. Churnosov

    Title:Proteins P53 and B-cell lymphoma-2 in pathogenesis missed and spontaneous abortions
    Journal:Drug Invention Today
    Vol(issue):9(3)
    Year:2017
    Page No: (65-68)
  • Experimental Methods Keywords

    Methodology:Apoptosis, Bax, B-cell lymphoma-2, Decidual tissue, Endometrium, MDM2, Missed abortion, Noxa, p21, p53, Spontaneous abortion
    Research Materials:Patients

Keywords

Apoptosis Bax B-cell lymphoma-2 Decidual tissue Endometrium MDM2 Missed abortion Noxa p21 p53 Spontaneous abortion

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