Journal: Drug Invention Today

Article Id: JPRS-DFA-00001971
Title: Self-microemulsifying drug delivery system for enhancement of oral bioavailability of losartan
Category: Drug or Formulation Analysis
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    Objective: The objective of the present study was to formulate self-microemulsifying drug delivery system (SMEDDS) to enhance the oral bioavailability of losartan. Experimental: The solubility of losartan was determined in various vehicles, and pseudoternary phase diagrams were used to assess the micro-emulsification boundary. The losartan SMEDDS was prepared using Capmul MCM EP (oil), tween 80 (surfactant), and polyethylene glycol (PEG) 400 (cosurfactant). Results: The SMEDDS was tested for microemulsifying properties, and the resultant microemulsions were evaluated for droplet size, zeta potential, transmission electron microscopy, and in vitro dissolution. The formulation development and screening were done on the basis of results obtained from phase diagrams and characteristics of resultant microemulsions. The selected formulation of Capmul MCM EP with surfactant and cosurfactant mixture (Smix) ratio of 1:1 (Tween-80: PEG-400) subjected to in vivo bioavailability study using rabbit. The results of drug release and oral bioavailability of losartan SMEDDS were compared with marketed formulation. The selected formulation enhanced the oral bioavailability of losartan by 1.49 folds than the marketed formulation.

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    Author(s) Name:

    Pawar Anil R1,2*, Chaudhari Pravin D3

    Affiliation(s) Name:

    1PRIST University, Thanjavur, Tamil Nadu, India,

    2Department of Pharmaceutics, MES College of Pharmacy, Affiliated to Savitribai Phule Pune University, Sonai, Newasa, Ahmednagar, Maharashtra, India,

    3 Department of Pharmaceutics, Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India

    *Corresponding author: Pawar Anil R., MES College of Pharmacy, Sonai, Newasa, Ahmednagar, Maharashtra, India.

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    Author:

    Pawar Anil R1,2*, Chaudhari Pravin D3

    Title:Self-microemulsifying drug delivery system for enhancement of oral bioavailability of losartan
    Journal:Drug Invention Today
    Vol(issue):9 (September )
    Year:2017
    Page No: (35-41)
  • Experimental Methods Keywords

    Methodology:Bioavailability, Losartan, Psudoternary phase diagram, Self-microemulsifying drug delivery system, Zeta potential
    Research Materials:Losartan

Keywords

Bioavailability Losartan Psudoternary phase diagram Self-microemulsifying drug delivery system Zeta potential

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