Journal: Journal of Pharmacy Research

Article Id: JPRS-PS-00001980
Title: A review on phytoconstituents: The potent synergistic approach in antimicrobial formulations
Category: Pharmaceutical Sciences
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  • Abstract

    Since the past few decades, microbial infections are the main threat to human life and cause a serious series of events. Antibiotics are the main weapon to fight these microbial infections and health of human life has been benefited. However, from past few decades antibiotics are becoming less and less effective in certain infections due to increasing resistance in microbes. This resistance is not specific to antibiotic used, also extended to other classes of antibiotics. Many of antibiotics produce toxic effects due to the emergence of multidrug resistance (MDR) bacteria and cause serious illness to human life. A common approach to treat diseases is to use antibiotics or plant extracts individually and/or an alternative approach is the use of antibiotics and plant extracts combinations or synergistic therapy. The latter therapy, i.e., combination synergistic approach; against multidrug‑resistant bacteria may provide an alternative path to treat infectious diseases and provide a useful area for further investigations in the future. Combination approach provides safe and alternative treatment for patients with severe infections caused by bacteria and fungi. The present review explains in detail, the noticed synergistic effects between natural plant extracts and common antibiotics therapy fighting common fungal and bacterial infections. The mechanism of action of the individual drug is significantly different from the combination therapy; therefore, selecting suitable combination is essential and crucial which entails understanding the mechanism of infection between antimicrobial agents and plant extracts.

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    Author(s) Name:

    Ankit Saini, Bhupendra Singh*, Ashis Suttee, Surajpal Verma, Lavi Kumar Garg, Sourav Thakur

    Affiliation(s) Name:

    Department of Pharmaceutical Sciences, Lovely Professional University, Phagwara ‑ 144 401, Punjab, India

    *Corresponding author: Dr. Bhupendra Singh, Department of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

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    Author:

    Ankit Saini, Bhupendra Singh*, Ashis Suttee, Surajpal Verma, Lavi Kumar Garg, Sourav Thakur

    Title:A review on phytoconstituents: The potent synergistic approach in antimicrobial formulations
    Journal:Journal of Pharmacy Research
    Vol(issue):12 (February )
    Year:2018
    Page No: (151-159)
  • Experimental Methods Keywords

    Methodology:Antimicrobials, Natural antimicrobials, Synergistic therapy
    Research Materials:Phytoconstituents

Keywords

Since the past few decades microbial infections are the main threat to human life and cause a serious series of events. Antibiotics are the main weapon to fight these microbial infections and health

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