Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001981
Title: An overview on various types of anticancer drugs and their drug-drug interactions: Melphalan, 5-fluorouracil, and hydrazine
Category: Pharmacology
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    Aim: In this review article we primarily try to give more importance in knowing about various drug interactions with anti cancer drugs such as Melphalan, 5-Fluorouracil and Hydrazine which help in increasing their efficiency of action on tumor cells. Materials and methods: As it is a review article we collaborated all the methodologies which were utilized drug combination studies which were used various research scholars. Results and discussion: This review is the therapeutic effects which are involved due to various drug combinations. Drug interactions occur in Pharmacokinetic and Pharmacodynamic levels. There are varied adverse effects which can be caused due to some of the Drug interactions Thus, systematic knowledge on Drug interactions particularly in every levels of absorption, elimination, transport and drug metabolism which may help in preventing these Adverse side effects. Conclusions: Combinations of dexamethasone with melphalan helped in treatment of POEMS syndrome. Melphalan also is helpful in Liposomal Drug delivery systems. One of the studies also proved the efficiency of Intraviteral and Sub-conjunctival injections in killing tumor cells. Cyclophoshamide pretreatment along with High dose of melphalan also helped in increase in efficiency of drug action on tumor cells. High dose of melphalan has also been proved to help in treatment of Neuroblastoma. We could also know the importance of carrier like PLGA by performing Biological evaluation of 5-Fluorouracil. Combination of Capaciatabine along with 5-FU helped in treatment of Oesophageal canecr. Studies on hydrazine proved to act as cancer causative agents. Oxaliplatin when given in combination with 5-FU helped in treatment of metastatic colorectal cancer. 5-FU loaded with microsponges helped in treatment of Colon cancer. Thus all these studies performed helped in providing efficient drug for treatment for various types of cancers.Thus there is an alarming need to perform studies on various relevant drug-drug interactions to treat a specific disease which would help in provision of treatment for any kind of disease which is affecting the patient.

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    Author(s) Name:

    Syed Tazib Rahaman1 *,Ruhita Pentakota2 , Praveen Vasireddy3

    Affiliation(s) Name:

    Department of Phrmacology, Gitam Institute of Pharmacy, Gitam University, Visakhapatnam, Andhra Pradesh, India

    *Corresponding author: Syed Tazib Rahaman, Gitam Institute of Pharmacy, Gitam University, Visakhapatnam, Andhra Pradesh, India

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    Author:

    Syed Tazib Rahaman1 *,Ruhita Pentakota2 , Praveen Vasireddy3

    Title:An overview on various types of anticancer drugs and their drug-drug interactions: Melphalan, 5-fluorouracil, and hydrazine
    Journal:Journal of Pharmacy Research
    Vol(issue):12 (February )
    Year:2018
    Page No: (160-167)
  • Experimental Methods Keywords

    Methodology:Anticancer drugs, Drug-drug interactions
    Research Materials:Melphalan, 5-fluorouracil, and hydrazine

Keywords

5-fluorouracil Anticancer drugs Drug-drug interactions Hydrazine Melphalan Synergistic effect

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