Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001982
Title: Formulation and evaluation of polymeric thin films of zolmitriptan
Category: Pharmaceutics
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    Background: A lot of work had been done in recent years in the development of oral thin films (OTFs) for drug delivery. Triptans, which are highly selective serotonin agonist used for migraine therapy, were used as a model drug for developing novel thin film drug delivery platform. Aim of the present work was to exploit the combination of hydrophilic polymer and β-cyclodextrin to formulated fast dissolving OTF of Zolmitriptan. Method: A total of nine batches of the thin films with different concentration of hydrophilic Methocel E5(HPMC E5) and β-cyclodextrin reportedly having taste-masking and bioenhancing effect were prepared using glycerin as plasticizer. The mechanical properties such as folding endurance, elongation, and tensile strength along with disintegration time were evaluated. Result and conclusion: In vitro dissolution studies carried out in simulated saliva and gastric fluid indicated that more than 80% of the drug was released in <10 min. A compromise was reached between moderate tensile strength and minimum disintegration time as both in vitro disintegration time and tensile strength of film increased with increase in the concentration of polymer. Thus, it was concluded that the one can successfully formulate novel thin film drug delivery system for triptans using a combination of Methocel E5 and β –cyclodextrin.

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    Author(s) Name:

    Garima Bansal 1,2 *, Vipin Kumar Garg1 , K. K. Jha2

    Affiliation(s) Name:

    1 Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut, Uttar Pradesh, India,

    2 College of Pharmacy, Teerthankar Mahaveer University, Moradabad, Uttar Pradesh, India

    *Corresponding author: Garima Bansal, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.

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    Author:

    Garima Bansal 1,2 *, Vipin Kumar Garg1 , K. K. Jha2

    Title:Formulation and evaluation of polymeric thin films of zolmitriptan
    Journal:Journal of Pharmacy Research
    Vol(issue):12 (February )
    Year:2018
    Page No: (160-167)
  • Experimental Methods Keywords

    Methodology:Formulation , evaluation
    Research Materials:Zolmitriptan

Keywords

β-cyclodextrin Methocel E5 Thin films Triptans

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