Journal: Journal of Pharmacy Research

Article Id: JPRS-PB-00001987
Title: Exploring innovative approach to combat multiple drug resistance of Staphylococcus aureus
Category: Pharmaceutical Biotechnology
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Aim: Bacteriocins are ribosomally synthesized antimicrobial peptides which are active against bacteria either of same or closely related species. The protection against the pathogen using bacteriocin was considered as an innovative approach, especially against the multidrug-resistant bacteria. Materials and Methods: Human skin sample has been swabbed and inoculated on Mannitol salt agar to isolate Staphylococcus epidermidis and later on they have been identified by biochemically and by 16S rRNA gene sequencing. Cell-free bacteriocin produced by the S. epidermidis has been checked against the multidrug-resistant Staphylococcus aureus by well diffusion assay. Result: S. epidermidis SE2 identified by 16S rRNA gene sequencing found to be producing the bacteriocin which is inhibiting multiple drug resistant S. aureus with the 13 mm zone of inhibition proving its medical potential. Conclusion: Human skin possesses S. epidermidis having bacteriocin producing ability and that can also be used to control multidrug-resistant S. aureus and proving its potential in medical biotechnology.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    Abhishek Mokase1 , Arti Shanware1 *, Archana Kulkarni 2

    Affiliation(s) Name:

    1Department of  Biotechnology, Rajiv Gandhi Biotechnology Center, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India,

    2Department of Microbiology, Dharampeth M.P. Deo Memorial Science College, Nagpur, Maharashtra, India

    *Corresponding author: Arti Shanware, Rajiv Gandhi Biotechnology Center, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur - 440033, Maharashtra, India.

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Abhishek Mokase1 , Arti Shanware1 *, Archana Kulkarni 2

    Title:Exploring innovative approach to combat multiple drug resistance of Staphylococcus aureus
    Journal:Journal of Pharmacy Research
    Vol(issue):12(2)
    Year:2018
    Page No: (194-197)
  • Experimental Methods Keywords

    Methodology:Antibacterial activity, Well diffusion assay
    Research Materials:Human skin, Staphylococcus aureus, Staphylococcus epidermidis

Keywords

Antibacterial activity Bacteriocin Staphylococcus aureus Staphylococcus epidermidis Well diffusion assay

Our Services

Most Downloaded List