Journal: Journal of Pharmacy Research

Article Id: JPRS-PHDRS-00001989
Title: Phytochemical screening and in vitro antioxidant activities of Senna singueana leaves
Category: Pharmacognosy and Herbal Drugs related study
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  • Abstract

    Objective: Senna singueana deciduous shrub that belongs to the Fabaceae family occurs throughout mainland tropical Africa commonly called as scrambled egg, conventionally, in African contents, it has many medicinal uses to cure different types of disease such as anticancer, antimalarial, bilharzia, fever, and wounds caused by leprosy and syphilis. The objective of the study was to perform the qualitative phytochemical analysis and in vitro antioxidant activities of S. singueana leaves. Materials and Methods: The present study was to evaluate the qualitative phytochemical analysis and in vitro antioxidants activities of ethanolic extract of S. singueana leaves by 1,1-diphenyl-2-picrylhydrazyl, reducing power assay, hydroxyl radical, nitric oxide, and superoxide radical scavenging activities using standard methods.. Results: From the phytochemical analysis of different organic extracts, the ethanolic extract contained maximum number of secondary metabolites such as flavonoids, tannins and phenolic compounds, and terpenoid, and further, the in vitro antioxidant activity of ethanolic extract of S. singueana showed significant scavenging activity on increasing order of OH>DPPH>NO>O2 compared to that of ascorbic acid (standard). Conclusion: Based on the present results, the ethanolic leaf extract of S. singueana contained flavonoids and phenols, thereby presented significant antioxidant activity, it can be used as a potential source of desired bioactive natural antioxidants for the development of therapeutic antioxidant drugs.

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    Author(s) Name:

    Debes Gerezgher1 , K. Krishna Chaithanya1 , Zenebe Hagos1 , K. Devaki 2 , V. K. Gopalakrishnan1 *

    Affiliation(s) Name:

    1 Department of Chemistry, College of Natural and Computational Sciences, Aksum University, Axum, Ethiopia,

    2 Department of Biochemistry and Bioinformatics, Karpagam University, Coimbatore, Tamil Nadu, India

    *Corresponding author: Dr. V. K. Gopalakrishnan, Department of Chemistry, College of Natural and Computational Sciences, Aksum University, Axum, Tigray Region, Ethiopia.

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    Author:

    Debes Gerezgher1 , K. Krishna Chaithanya1 , Zenebe Hagos1 , K. Devaki 2 , V. K. Gopalakrishnan1 *

    Title:Phytochemical screening and in vitro antioxidant activities of Senna singueana leaves
    Journal:Journal of Pharmacy Research
    Vol(issue):12(2)
    Year:2018
    Page No: (211-215)
  • Experimental Methods Keywords

    Methodology: 2,2-diphenyl-1-picrylhydrazyl, Antioxidants, Phytochemical analysis
    Research Materials:Senna singueana

Keywords

2 2-diphenyl-1-picrylhydrazyl Antioxidants Ethanolic extract Phytochemical analysis Senna singueana

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