Journal: Drug Invention Today

Article Id: JPRS-PS-00002028
Title: Pharmacological evaluation of curcumin for its nephroprotective activity in 5/6 nephrectomized rat model
Category: Pharmacological Screening
Section: Research Article
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    Objective: Plants with renal protective activities provide important sources for the development of new drugs in the treatment of renal failure. The protective effect of curcumin isolated from the rhizome of Curcuma longa was studied on experimental renal failure rats. Experiment: The study was planned to investigate the effect of curcumin in Wistar rats in 5/6 nephrectomy. The curcumin was administered at 100 mg/kg and 200 mg/kg orally for 60 days. After 60 days parameters such as creatinine, urea, uric acid, sodium, potassium, and calcium were estimated. Results: Treatment with curcumin 200 mg/kg showed significantly reduced creatinine, urea, and uric acid compared to nephrectomized control. Moreover, the significant decrease in calcium, sodium, and potassium was observed at 200 mg/kg curcumin (P < 0.01). Conclusion: In conclusion, curcumin that is obtained from the rhizome C. longa is having multiple therapeutic benefits and is a potential herbal medicine in curing renal failure in 5/6 nephrectomized rat model.

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    Author(s) Name:

    A. Shanish Antony1 *, S. Gomathy2 , T. P. Rajmohan1 , P. Anoop3 , Cijo Issaic4

    Affiliation(s) Name:

    1 Department of Pharmacy, Government Medical College, Kottayam, Kerala, India,

    2 Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Rocklands, Ooty, Tamil Nadu, India,

    3 Department of Pharmaceutics, Government Medical College, Kozhikode, Kerala, India,

    4 Department of Pharmaceutics, Govt Medical College, Kottayam, Kerala, India

    *Corresponding author: Dr. A. Shanish Antony, Department of Pharmacy, Government Medical College, Kottayam, Kerala – 686 008, India.

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    Author:

    A. Shanish Antony1 *, S. Gomathy2 , T. P. Rajmohan1 , P. Anoop3 , Cijo Issaic4

    Title:Pharmacological evaluation of curcumin for its nephroprotective activity in 5/6 nephrectomized rat model
    Journal:Drug Invention Today
    Vol(issue):10 (Jan)
    Year:2018
    Page No: (10-13)
  • Experimental Methods Keywords

    Methodology: creatinine, urea, uric acid, sodium, potassium, and calcium analysis
    Research Materials: Curcuma longa

Keywords

5/6 Nephrectomy Chronic renal failure Curcumin

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