Journal: Drug Invention Today

Article Id: JPRS-CDRS-00002036
Title: Hypolipidemic of ethanolic extract of Salam bark (Syzygium polyanthum (Wight) Walp.) from Indonesia (Preclinical study)
Category: Clinical Drugs Related Study
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    Aim: The aim of this research to evaluate the effect of 70% ethanol extract of Salam bark (Syzygium polyanthum (Wight) Walp.) ethanolic extract of Salam bark (EESB) from Indonesia toward blood cholesterol, triglyceride, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels in male rats Wistar strain. Materials and Methods: This study was a preclinical experimental study with a pre- and post-test with control group design. A total of 25 white male rats Wistar strain were divided into five groups with simple random sampling. The groups were negative control (aquadest), positive control (simvastatin 0.2 mg/200 g bw/day), dose I (0.36 g/200 g bw/day), dose II (0.72 g/200 g bw/day), and dose III (1.44 g/200 g bw/day). Blood cholesterol, triglyceride, LDL, and HDL levels were measured before and after applying treatment. This study was held for 15 days and data were analyzed by one-way ANOVA test followed by least significant difference test and Kruskal–Wallis followed by Mann–Whitney test. Results: The 70% EESB (S. polyanthum (Wight) Walp.) at dosage of 0.72 and 1.44 g/200 g bw/day can decrease blood cholesterol; triglyceride and LDL levels (P < 0.05), meanwhile, the extract at dosage of 0.36, 0.72, and 1.44 g/200 g bw/day can increase serum HDL levels (P < 0.05). Conclusions: The 70% EESB (S. polyanthum (Wight) Walp.) decreases the serum cholesterol, triglyceride, LDL, and increase HDL levels significantly in hypercholesterolemia male rats Wistar strain.

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    Author(s) Name:

    Em Sutrisna*, Yoga Nuswantoro, Robbi Fatqurahman Said

    Affiliation(s) Name:

    Department of Pharmacology, Faculty of Medicine of Universitas Muhammadiyah Surakarta, Indonesia

    *Corresponding author: Em Sutrisna, Department of Pharmacology of Faculty of Medicine of Universitas Muhammadiyah Surakarta, Indonesia.

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    Author:

    Em Sutrisna*, Yoga Nuswantoro, Robbi Fatqurahman Said

    Title:Hypolipidemic of ethanolic extract of Salam bark (Syzygium polyanthum (Wight) Walp.) from Indonesia (Preclinical study)
    Journal:Drug Invention Today
    Vol(issue):10 (Jan)
    Year:2018
    Page No: (55-58)
  • Experimental Methods Keywords

    Methodology:Hypolipidemic activity
    Research Materials: Salam bark (Syzygium polyanthum (Wight) Walp.)

Keywords

Cholesterol High-density lipoprotein Low-density lipoprotein Salam Syzygium polyanthum (Wight) Walp.) Triglyceride

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