Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00002042
Title: The role of solvent dielectric constant in modeling of the extraction process of phenolic compounds from silybum marianum l. Fruits
Category: Pharmaceutical Chemistry
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    Objective: The objective of this work was to study the influence of solvent physicochemical properties on qualitative and quantitative content of extracts by high-performance liquid chromatography (HPLC) for substantiation of a rational technology of silibinin extraction from Silybum marianum l. fruits. Methods: For experiments, we used ground plant raw material with 0.1–0.5 mm particle size, distilled water, ethanol, n-hexane, methanol, 1-propanol, 2-propanol, acetone, and ethyl acetate. Qualitative analyses of substances were carried out by reversed-phase HPLC on a chromatograph of Agilent technologies 1200 infinity type. Results: Flavonolignans dominated among the phenolic compounds detected in the extracts. In this study, it was found that a ketone functional group in the solvent’s molecule has a stronger influence on the extraction of flavonolignans from the plant raw material matrix into the solvent than a hydroxyl group, and a linear structure of hydrophobic part of molecules was preferred to a non-linear one. An optimal range of the dielectric constant of the solvent for maximum extraction of silibinin from the plant raw material was determined, and it equals ε = 40 ± 4 units. Conclusion: It has been shown that dependence between the natural logarithm of silibinin concentration and the reverse dielectric constant value of the ethanol–water solution approximates well by a quadric equation. The following sequence of preferred solvents as for their extraction properties for silibinin was arranged: Acetone ≥ethanol 70% v/v ≥ methanol 86% v/v ≥ methanol ≥ 2-propanol 68% v/v ≥ acetone 68% v/v ≥ 1-propanol ≥ ethyl acetate ≥2-propanol.

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    Author(s) Name:

    Nikolay N. Boyko¹*, Dmitriy I. Pisarev¹, Elena T. Zhilyakova¹, Oleg O. Novikov¹, Zoja E. Tsvetkova¹, Victoria Yu. Kuznietsova², Natalia A. Sushchuk³

    Affiliation(s) Name:

    ¹Department of Pharmacy, Scientific and Educational Centre “Pharmacy,” Belgorod State University, Belgorod, Russia,

    ²Department of Chemistry of Natural Compounds of the National University of Pharmacy, Kharkiv 61002, Ukraine,

    ³Department of Technology of Drugs, Odessa National Medical University, Odessa 65000, Ukraine

    *Corresponding author: Nikolay N. Boyko, Scientific and Educational Centre “Pharmacy”, Belgorod State University, Belgorod, Russia.

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    Author:

    Nikolay N. Boyko¹*, Dmitriy I. Pisarev¹, Elena T. Zhilyakova¹, Oleg O. Novikov¹, Zoja E. Tsvetkova¹, Victoria Yu. Kuznietsova², Natalia A. Sushchuk³

    Title:The role of solvent dielectric constant in modeling of the extraction process of phenolic compounds from silybum marianum l. Fruits
    Journal:Journal of Pharmacy Research
    Vol(issue):12(4)
    Year:2018
    Page No: (440-0)
  • Experimental Methods Keywords

    Methodology: Qualitative analysis,Dielectric constant,reversed-phase HPLC analysis
    Research Materials:Silybum marianum

Keywords

Dielectric constant Silibinin Silybum marianum l. fruits Solvent

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