Journal: Journal of Pharmacy Research

Article Id: JPRS-PA-00002043
Title: Four validated spectrophotometric methods for determination of ambroxol, guaifenesin, and theophylline in their ternary mixture in bulk powder and dosage form
Category: Pharmaceutical Analysis
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    The purpose of the present study was to develop and validate spectrophotometric methods for simultaneous determination of a ternary mixture of ambroxol HCl (AMB), guaifenesin (GUA) and theophylline (THEO) in pharmaceutical dosage forms. (a) Direct spectrophotometry (DS), (b) dual wavelength (DW), (c) first derivative of ratio spectra ( 1 DD), and (d) absorption correction (AC). DS method was applied to determine AMB at its λmax (309.0 nm) without any interference of THEO and GUA. Both THEO and GUA were determined as a binary mixture after removal of AMB contribution from the ternary mixture by ratio subtraction technique. DW method was applied to determine GUA by measuring the difference in absorbance at 224.5 nm and 255.0 nm. 1 DD was used to determine THEO at 295.4 nm and GUA at 236.5 nm using 14.0 μg/mL GUA and 14.5 μg/mL THEO as divisors, respectively. AC was applied after the second derivative for determination of GUA at 239.5 nm and THEO at 239.5 nm and 266.0 nm. The methods were accurate, specific, and successfully applied for the determination of the three drugs in laboratory prepared mixtures and their combined dosage form.

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    Author(s) Name:

    Shereen A. Boltia1 , Ahmed S. Fayed1 , Maha A. Hegazy1 , Awadh Musaed2 *

    Affiliation(s) Name:

    1Department of Analytical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt,

    2Department of Analytical Chemistry, Faculty of Pharmacy, Aden University, Yemen

    *Corresponding author: Awadh Musaed, Kar Al-aini Street, 11562, Cairo, Egypt.

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    Author:

    Shereen A. Boltia1 , Ahmed S. Fayed1 , Maha A. Hegazy1 , Awadh Musaed2 *

    Title:Four validated spectrophotometric methods for determination of ambroxol, guaifenesin, and theophylline in their ternary mixture in bulk powder and dosage form
    Journal:Journal of Pharmacy Research
    Vol(issue):12 (April)
    Year:2018
    Page No: (446-454)
  • Experimental Methods Keywords

    Methodology:Ultraviolet (UV)- 1800 spectrophotometer
    Research Materials: Ambroxol, Derivative,Guaifenesin

Keywords

Ambroxol Derivative Dual wavelength Guaifenesin Ratio subtraction Theophylline

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