Journal: Journal of Pharmacy Research

Article Id: JPRS-MB-00002055
Title: Study on efficacy of herbal and copper nanoparticle ointment against wound pathogen isolated from diabetic foot ulcer
Category: Microbiology
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    Aim: This study aims to check the antibacterial activity of ointment produced with herbs such as Siriyanangai, Kandankathiri, and naval seed, and copper nanoparticles against diabetic foot ulcer pathogens such as Staphylococcus aureus and Escherichia coli. Materials and Methods: The foot ulcer sample was collected from diabetic patients by swab method. In this current research, screening of herbal plant extractions which are supposed to be having antimicrobial property has been analyzed. The screened herbal extract was incorporated into prepared copper nanoparticles by the method of nanoencapsulation. The herbal composite was optimized by varying the concentration of herb and nanoparticles. The characterizations of the prepared composite were achieved by instrumentation analysis. Further, the composite was prepared into an ointment using petroleum jelly as a base and its antibacterial activity was analyzed against diabetic foot pathogens. Result and Discussion: About 10 µL of the ointment showed a zone of inhibition of 14 mm and 15 mm for S. aureus and E. coli, respectively. This shows that the prepared herbal ointment has antibacterial activity against foot ulcer pathogens. Conclusion: The findings of this research may provide an economically viable method for the treatment of diabetic foot ulcer.

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    Author(s) Name:

    K. Pragathesh Singh1 *, D. Latha1 , A. S. Jayasree1 , V. Muthu Laxmi 1 , Tamil Selvi 2 , S. Vijayalakshmi 3 , Radhika Jevanand3

    Affiliation(s) Name:

    1 School of Biological Science, C.M.S College of Science and Commerce, Coimbatore, Tamil Nadu, India,

    2 Department of Biotechnology, P.S.G College of Arts and Science, Coimbatore-641 014, India,

    3 Department of Microbiology, D. G. Vaishnav College, Arumbakkam, Chennai, Tamil Nadu, India

    *Corresponding author: K. Pragathesh Singh, Division of Microbiology, School of Biological Sciences, CMS College of Science and Commerce, Coimbatore, Tamil Nadu, India.

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    Author:

    K. Pragathesh Singh1 *, D. Latha1 , A. S. Jayasree1 , V. Muthu Laxmi 1 , Tamil Selvi 2 , S. Vijayalakshmi 3 , Radhika Jevanand3

    Title:Study on efficacy of herbal and copper nanoparticle ointment against wound pathogen isolated from diabetic foot ulcer
    Journal:Journal of Pharmacy Research
    Vol(issue):12(4)
    Year:2018
    Page No: (516-519)
  • Experimental Methods Keywords

    Methodology:Nanoencapsulation, instrumentation analysis,antibacterial activity
    Research Materials:herbal ,Copper nanoparticles,ointment,

Keywords

Copper nanoparticles Escherichia coli herbal extraction ointment Staphylococcus aureus yellow petroleum jelly

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