Journal: Drug Invention Today
Title: Proteins P53 and BCL-2 in pathogenesis of missed and spontaneous abortions
Category: Biomaterials ( Synthetic and Natural )
Section: Research Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
mRNA expression of p53, p21, BCL-2, Bax, Noxa and MDM2 in decidual tissue (endometrium) of 50 patients with missed abortions, 47 patients with spontaneous abortions, and 57 patients with artificial abortion (control group) at 6–10 weeks of gestation were examined using reverse transcription quantitative polymerase chain reaction. Expression of p53 mRNA had no significant differences in patients with missed and spontaneous abortions. Significant increase of proapoptotic protein Noxa, accompanied with anti-apoptotic protein BCL-2 elevation was observed in the endometrium of patients with missed abortions. In patients with spontaneous abortions, only increase of Noxa has been observed. It can be suggested, that increase of BCL-2 in patients with missed abortions, when embryo resorption has happened, protects nearby embryos in case of multiple pregnancies. No significant changes of p21 mRNA were discovered in both groups, which indicates, that cell cycle arrest is not involved in the pathogenesis of early miscarriages. No significant changes of Bax and MDM2 mRNA expression were discovered in decidual tissue of patients with missed and spontaneous abortions.
-
Abstract Audio
No Audio file found
About the authors and Affiliations
Author(s) Name: Olga P. Lebedeva*, Irina O. Zhukova, Olesya N. Ivashova, Sergey P. Pakhomov, Mikhail I. Churnosov
Affiliation(s) Name: Department of Obstetrics and Gynecology, Institute of Medicine, Belgorod State National University, 308015, Pobedy Street, 85, Belgorod, Russia
*Corresponding author: Olga P. Lebedeva, Institute of Medicine, Belgorod State National University, 308015, Pobedy Street, 85, Belgorod, Russia.-
View Article File in pdf format.
Article File
-
View Article Citation Here.
0 View More -
How to Cite my Article.
Author: Olga P. Lebedeva*, Irina O. Zhukova, Olesya N. Ivashova, Sergey P. Pakhomov, Mikhail I. Churnosov
Title: Proteins P53 and BCL-2 in pathogenesis of missed and spontaneous abortions Journal: Drug Invention Today Vol(issue): 9 (December) Year: 2017 Page No: (65-68) -
Experimental Methods Keywords
Methodology: Reverse transcription quantitative polymerase chain reaction Research Materials: Patients with abortions
Keywords
Our Services
- Correlation of facial and nasal index in gender determination
- Abutment selection in fixed partial denture - A review
- Morphometric analysis of gonial angle and mandibular ramus measurement as predictors of sex and age in dry human mandibles
- Estimation of orbital index for gender determination
- Benzoic acid, one of the major components of aqueous bark extract of Terminalia arjuna protects against Copper-Ascorbate induced oxidative stress in human placental mitochondria through antioxidant m
- Craniometric analysis of foramen magnum with reference to occipital condyles for the determination of sex using dry human skulls
- Morphological and morphometrical analysis of Chassaignac’s tubercle in dry human cervical vertebrae
- Studies on antioxidant and anthelmintic activity of two Streptomyces species isolated from Western Ghat soils of Agumbe, Karnataka
- Evaluation of phytochemical and pharmacological aspects of Holarrhena antidysenterica (Wall.): A comprehensive review
- Review On: Fast Dissolving Tablet
- Extraction of Betacyanin from Red Beet root (Beta vulgaris L.) and to evaluate its antioxidant potential antioxidant potential
- Formulation development and evaluation of Carbamazepine fast dissolving tablets
- Awareness on soil pollution among school students
- Knowledge, attitude, and practices toward oral hygiene maintenance among patients visiting a dental college
- Awareness and knowledge about usage of e-cigarettes and risk of cardiovascular disease among smokers
- Self micro-emulsifying drug delivery system (SMEDDS) : Review
- QbD Approach for Analytical Method Development and Validation of Melatonin by spectroscopic Method
- Awareness about oral cancer among tobacco users visiting a private dental hospital in Chennai
- Thiophene: The molecule of diverse medicinal importance
- Prevalence pattern of developmental anomalies of oral cavity in South Indian population - A hospital-based study
- A study of the factors affecting time to onset of lactogenesis-II after parturition
- Standardization of Nandhi Mezhugu, a poly herbomineral Siddha formulation
- Awareness of anemia among dental undergraduate students: A questionnaire-based study
- In vitro anti-Candida activity of Calotropis gigantea.
- Knowledge and awareness among undergraduate dental students regarding oral health of diabetes mellitus patients
- Evaluating the effects of video games on blood pressure and heart rate
- Awareness and knowledge of the usage of e-cigarettes and risk in oral cavity among smokers – A survey
- Pharmaceutical and medicinal applications of Olibanum gum and its constituents : A review
- Anticancer activity of L-theanine in MG-63 cell line
- Combinatory effect of embelin with antibiotics against Staphylococcus aureus