Journal: Drug Invention Today

Article Id: JPRS-BSN-00002066
Title: Proteins P53 and BCL-2 in pathogenesis of missed and spontaneous abortions
Category: Biomaterials ( Synthetic and Natural )
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    mRNA expression of p53, p21, BCL-2, Bax, Noxa and MDM2 in decidual tissue (endometrium) of 50 patients with missed abortions, 47 patients with spontaneous abortions, and 57 patients with artificial abortion (control group) at 6–10 weeks of gestation were examined using reverse transcription quantitative polymerase chain reaction. Expression of p53 mRNA had no significant differences in patients with missed and spontaneous abortions. Significant increase of proapoptotic protein Noxa, accompanied with anti-apoptotic protein BCL-2 elevation was observed in the endometrium of patients with missed abortions. In patients with spontaneous abortions, only increase of Noxa has been observed. It can be suggested, that increase of BCL-2 in patients with missed abortions, when embryo resorption has happened, protects nearby embryos in case of multiple pregnancies. No significant changes of p21 mRNA were discovered in both groups, which indicates, that cell cycle arrest is not involved in the pathogenesis of early miscarriages. No significant changes of Bax and MDM2 mRNA expression were discovered in decidual tissue of patients with missed and spontaneous abortions.

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    Author(s) Name:

    Olga P. Lebedeva*, Irina O. Zhukova, Olesya N. Ivashova, Sergey P. Pakhomov, Mikhail I. Churnosov

    Affiliation(s) Name:

    Department of Obstetrics and Gynecology, Institute of Medicine, Belgorod State National University, 308015, Pobedy Street,  85, Belgorod, Russia


    *Corresponding author: Olga P. Lebedeva, Institute of Medicine, Belgorod State National University, 308015, Pobedy Street, 85, Belgorod, Russia.

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    Author:

    Olga P. Lebedeva*, Irina O. Zhukova, Olesya N. Ivashova, Sergey P. Pakhomov, Mikhail I. Churnosov

    Title:Proteins P53 and BCL-2 in pathogenesis of missed and spontaneous abortions
    Journal:Drug Invention Today
    Vol(issue):9(3)
    Year:2017
    Page No: (65-68)
  • Experimental Methods Keywords

    Methodology: Reverse transcription quantitative polymerase chain reaction
    Research Materials:Patients with abortions

Keywords

Apoptosis Bax BCL-2 Decidual tissue Endometrium MDM2 Missed abortion Noxa p21 p53 Spontaneous abortion`

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