Journal: Drug Invention Today
Title: Proteins P53 and BCL-2 in pathogenesis of missed and spontaneous abortions
Category: Biomaterials ( Synthetic and Natural )
Section: Research Article
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Abstract
mRNA expression of p53, p21, BCL-2, Bax, Noxa and MDM2 in decidual tissue (endometrium) of 50 patients with missed abortions, 47 patients with spontaneous abortions, and 57 patients with artificial abortion (control group) at 6–10 weeks of gestation were examined using reverse transcription quantitative polymerase chain reaction. Expression of p53 mRNA had no significant differences in patients with missed and spontaneous abortions. Significant increase of proapoptotic protein Noxa, accompanied with anti-apoptotic protein BCL-2 elevation was observed in the endometrium of patients with missed abortions. In patients with spontaneous abortions, only increase of Noxa has been observed. It can be suggested, that increase of BCL-2 in patients with missed abortions, when embryo resorption has happened, protects nearby embryos in case of multiple pregnancies. No significant changes of p21 mRNA were discovered in both groups, which indicates, that cell cycle arrest is not involved in the pathogenesis of early miscarriages. No significant changes of Bax and MDM2 mRNA expression were discovered in decidual tissue of patients with missed and spontaneous abortions.
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About the authors and Affiliations
Author(s) Name: Olga P. Lebedeva*, Irina O. Zhukova, Olesya N. Ivashova, Sergey P. Pakhomov, Mikhail I. Churnosov
Affiliation(s) Name: Department of Obstetrics and Gynecology, Institute of Medicine, Belgorod State National University, 308015, Pobedy Street, 85, Belgorod, Russia
*Corresponding author: Olga P. Lebedeva, Institute of Medicine, Belgorod State National University, 308015, Pobedy Street, 85, Belgorod, Russia.-
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Author: Olga P. Lebedeva*, Irina O. Zhukova, Olesya N. Ivashova, Sergey P. Pakhomov, Mikhail I. Churnosov
Title: Proteins P53 and BCL-2 in pathogenesis of missed and spontaneous abortions Journal: Drug Invention Today Vol(issue): 9 (December) Year: 2017 Page No: (65-68) -
Experimental Methods Keywords
Methodology: Reverse transcription quantitative polymerase chain reaction Research Materials: Patients with abortions
Keywords
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