Journal: Drug Invention Today
Title: Proteins P53 and BCL-2 in pathogenesis of missed and spontaneous abortions
Category: Biomaterials ( Synthetic and Natural )
Section: Research Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
mRNA expression of p53, p21, BCL-2, Bax, Noxa and MDM2 in decidual tissue (endometrium) of 50 patients with missed abortions, 47 patients with spontaneous abortions, and 57 patients with artificial abortion (control group) at 6–10 weeks of gestation were examined using reverse transcription quantitative polymerase chain reaction. Expression of p53 mRNA had no significant differences in patients with missed and spontaneous abortions. Significant increase of proapoptotic protein Noxa, accompanied with anti-apoptotic protein BCL-2 elevation was observed in the endometrium of patients with missed abortions. In patients with spontaneous abortions, only increase of Noxa has been observed. It can be suggested, that increase of BCL-2 in patients with missed abortions, when embryo resorption has happened, protects nearby embryos in case of multiple pregnancies. No significant changes of p21 mRNA were discovered in both groups, which indicates, that cell cycle arrest is not involved in the pathogenesis of early miscarriages. No significant changes of Bax and MDM2 mRNA expression were discovered in decidual tissue of patients with missed and spontaneous abortions.
-
Abstract Audio
No Audio file found
About the authors and Affiliations
Author(s) Name: Olga P. Lebedeva*, Irina O. Zhukova, Olesya N. Ivashova, Sergey P. Pakhomov, Mikhail I. Churnosov
Affiliation(s) Name: Department of Obstetrics and Gynecology, Institute of Medicine, Belgorod State National University, 308015, Pobedy Street, 85, Belgorod, Russia
*Corresponding author: Olga P. Lebedeva, Institute of Medicine, Belgorod State National University, 308015, Pobedy Street, 85, Belgorod, Russia.-
View Article File in pdf format.
Article File
-
View Article Citation Here.
0 View More -
How to Cite my Article.
Author: Olga P. Lebedeva*, Irina O. Zhukova, Olesya N. Ivashova, Sergey P. Pakhomov, Mikhail I. Churnosov
Title: Proteins P53 and BCL-2 in pathogenesis of missed and spontaneous abortions Journal: Drug Invention Today Vol(issue): 9 (December) Year: 2017 Page No: (65-68) -
Experimental Methods Keywords
Methodology: Reverse transcription quantitative polymerase chain reaction Research Materials: Patients with abortions
Keywords
Our Services
- Medicinal uses of banana (Musa paradisiaca)
- Extraction of Betacyanin from Red Beet root (Beta vulgaris L.) and to evaluate its antioxidant potential antioxidant potential
- Standardization of Nandhi Mezhugu, a poly herbomineral Siddha formulation
- A short review on smoker’s melanosis
- Inflammatory biomarkers in oral submucous fibrosis patients
- Melatonin affords protection against myocardial ischemia-induced cerebral mitochondrial dysfunction: an in vivo study.
- Cytotoxic evaluation of onion oil on oral cancer cell
- Effect of stress on academic performance of students in different streams
- Attenuation of diabetic nephropathy by a plant sterol lupeol: A biochemical analysis
- Formulation and evaluation of topical gel of diclofenac sodium using different polymers
- Abrus precatorius Linnaeus: A Phytopharmacological Review
- Essential Oil Extraction, Characterization and Anti microbial study of Cythocline purpurea from Konkan Region
- Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats
- Review On: Fast Dissolving Tablet
- Development and validation of a sensitive RP-HPLC method for quantitative determination of imatinib mesylate in complex dosage forms like drug eluting coronary stents
- Sleep deprivation and cell phone usage among teenagers
- A review on cellulose and its utilization from agro‑industrial waste
- Simultaneous Spectrophotometric Estimation of Paracetamol and Aceclofenac in Combined Tablet Formulations using Hydrotropic Solubilization Technique
- Pulsatile drug delivery system - A review article
- Development and Validation of Stability Indicating UV Spectrophotometric Method for the Estimation of Sitagliptin Phosphate in Bulk and Tablet Dosage Form
- Design, Evaluation, Parameters and Marketed Products of transdermal patches: A Review
- An overview on nanocarrier technology- Aquasomes
- A review on quality by design approach for analytical method development
- MICROSCOPICAL AND PRELIMINARY PHYTOCHEMICAL STUDIES ON LEAVES OF BRYOPHYLLUM CALYCINUM SALISB
- Clitoria ternatea (L.): Old and new aspects
- EVALUATION OF WOUND HEALING ACTIVITY OF CALOTROPAIN – P
- Salivary hemoglobin: A biomarker in periodontitis
- FORMULATION OF TOOTHPASTE FROM VARIOUS FORMS AND EXTRACTS OF TENDER TWIGS OF NEEM.
- Phytoremediation potential of three leguminous plants towards Chromium
- impurities of sulphid drug substances