Journal: Drug Invention Today
Title: Proteins P53 and BCL-2 in pathogenesis of missed and spontaneous abortions
Category: Biomaterials ( Synthetic and Natural )
Section: Research Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
mRNA expression of p53, p21, BCL-2, Bax, Noxa and MDM2 in decidual tissue (endometrium) of 50 patients with missed abortions, 47 patients with spontaneous abortions, and 57 patients with artificial abortion (control group) at 6–10 weeks of gestation were examined using reverse transcription quantitative polymerase chain reaction. Expression of p53 mRNA had no significant differences in patients with missed and spontaneous abortions. Significant increase of proapoptotic protein Noxa, accompanied with anti-apoptotic protein BCL-2 elevation was observed in the endometrium of patients with missed abortions. In patients with spontaneous abortions, only increase of Noxa has been observed. It can be suggested, that increase of BCL-2 in patients with missed abortions, when embryo resorption has happened, protects nearby embryos in case of multiple pregnancies. No significant changes of p21 mRNA were discovered in both groups, which indicates, that cell cycle arrest is not involved in the pathogenesis of early miscarriages. No significant changes of Bax and MDM2 mRNA expression were discovered in decidual tissue of patients with missed and spontaneous abortions.
-
Abstract Audio
No Audio file found
About the authors and Affiliations
Author(s) Name: Olga P. Lebedeva*, Irina O. Zhukova, Olesya N. Ivashova, Sergey P. Pakhomov, Mikhail I. Churnosov
Affiliation(s) Name: Department of Obstetrics and Gynecology, Institute of Medicine, Belgorod State National University, 308015, Pobedy Street, 85, Belgorod, Russia
*Corresponding author: Olga P. Lebedeva, Institute of Medicine, Belgorod State National University, 308015, Pobedy Street, 85, Belgorod, Russia.-
View Article File in pdf format.
Article File
-
View Article Citation Here.
0 View More -
How to Cite my Article.
Author: Olga P. Lebedeva*, Irina O. Zhukova, Olesya N. Ivashova, Sergey P. Pakhomov, Mikhail I. Churnosov
Title: Proteins P53 and BCL-2 in pathogenesis of missed and spontaneous abortions Journal: Drug Invention Today Vol(issue): 9 (December) Year: 2017 Page No: (65-68) -
Experimental Methods Keywords
Methodology: Reverse transcription quantitative polymerase chain reaction Research Materials: Patients with abortions
Keywords
Our Services
- Analysis of Amino Acids By Paper Chromatography
- Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats
- Biodegradable plastic production from corn starch
- Standardization of Nandhi Mezhugu, a poly herbomineral Siddha formulation
- Awareness of effects of sleep deprivation among college students
- Awareness on soil pollution among school students
- Awareness on the effects of skipping breakfast among adolescents
- Awareness of selfie addiction among teenagers: A questionnaire-based study
- Review on various techniques of solubility enhancement of poorly soluble drugs with special emphasis on solid dispersion
- Effect of stress on academic performance of students in different streams
- Awareness and knowledge about usage of e-cigarettes and risk of cardiovascular disease among smokers
- Multiple-Unit-Pellet System (MUPS): A Novel Approach for Drug Delivery
- Soxhlet Extraction of Neem seed (Azadirachta indica A. Juss) Using Hexane as a Solvent.
- Eucalyptus genus: a review
- A survey on awareness and perception about tattoos among college students
- Dental Caries and Medicinal Plants –An Overview
- Formulation and evaluation of topical gel of diclofenac sodium using different polymers
- A review on Rubia cordifolia: Its phyto constituents and therapeutic uses
- Abrus precatorius Linnaeus: A Phytopharmacological Review
- A review on cellulose and its utilization from agro‑industrial waste
- Evaluation of pulmonary function test in construction workers
- Investigation of SOD2 gene polymorphism in patients with chronic kidney disease in Babylon province
- Pulsatile drug delivery system for chronopharmacological disorders: an overview
- The effect of red betel leaves (Piper crocatum Ruiz and Pav.) on blood sugar and insulin expression levels in rat (Rattus norvegicus domesticus) models of diabetes mellitus
- Piper betle L.: A review on its ethnobotany, phytochemistry, pharmacological profile and profiling by new hyphenated technique DART-MS (Direct Analysis in Real Time Mass Spectrometry).
- Prevalence of aminoglycoside modifying enzyme genes in Pseudomonas aeruginosa isolated from Burn Centers in Iraq
- Citric acid production from cane molasses using submerged fermentation by Aspergillus niger ATCC9142
- In vitro Antioxidant Activity from Leaves of Oroxylum indicum (L.) Vent. -A North Indian Highly Threatened and Vulnerable Medicinal Plant
- Review On: Fast Dissolving Tablet
- Cow Urine Concentrate : A potent agent with Antimicrobial and Anthelmintic activity