Journal: Drug Invention Today

Article Id: JPRS-BI-00002067
Title: In silico molecular docking studies of compounds from Sargassum ilicifolium (Turner) C. agardh against biomarker enzymes in amnesia
Category: Bioinformatics
Section: Research Article
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    Objective: Molecular docking is a bioinformatics tool used to study and analyze ligand-receptor interactions and used as a valuable tool in drug discovery. Marine algae are taxonomically diverse biologically active and unique chemically offers a great scope for the discovery of novel drugs. Phytochemists and drug developers are now interestingly working in developing new molecules that can act effectively than conventional drugs. Alzheimer’s is a worldwide health problem associated with amnesia and aphasia. Acetylcholinesterase, butyrylcholinesterase, and beta-secretase are the enzymes that have the pathological role in amnesia. Inhibition of these enzymes plays a target role in treating Alzheimer’s. Methods: Sargassum ilicifolium Turner C. agardh belonging to Sargassaceae family has potential therapeutic uses in neuropharmacology. The compounds SCH1 and SCH2 were isolated from ethyl acetate fraction and subjected to mole grow software to study the molecular interaction between these ligands and the receptor site against acetylcholinesterase, butyrylcholinesterase, and beta-secretase enzymes. Results and Conclusions: Based on the docking scores and ligand interactions, the potency of the compounds was judged. The result concluded that both the compounds SC1 and SC2 have good binding interaction with biomarker enzymes and proved for its anti-amnesic activity in molecular modeling study.

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    Author(s) Name:

    M. Sumithra1 *, A. Vijayalakshmi 2

    Affiliation(s) Name:

    1 Department of Pharmacology, SRM College of Pharmacy, SRM University, Kattankulathur, Chengalpattu, Tamil Nadu, India,

    2 Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. M. Sumithra, Department of Pharmacology, SRM College of Pharmacy, SRM University, Kattangulathur - 603203. Chengalpattu, Tamil Nadu, India

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    Author:

    M. Sumithra1 *, A. Vijayalakshmi 2

    Title:In silico molecular docking studies of compounds from Sargassum ilicifolium (Turner) C. agardh against biomarker enzymes in amnesia
    Journal:Drug Invention Today
    Vol(issue):10 (Jan)
    Year:2018
    Page No: (62-67)
  • Experimental Methods Keywords

    Methodology:Molecular docking,In vitro Acetylcholine Esterase Assay,Isolation of Compounds
    Research Materials: Sargassum ilicifolium

Keywords

Amnesia Marine algae Molecular docking Sargassum ilicifolium

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