Journal: Journal of Pharmacy Research

Article Id: JPRS-PHDRS-0000207
Title: Evaluation of acute and subacute toxicity of aqueous extracts from Marrubium vulgare L in rodents
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
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    Aim: The aim of this study was to investigate the safety of the aqueous extract of Marrubium vulgare by determining its pharmaco-toxicological effects after acute and sub-acute administration in mice and rats, respectively. Materials and methods: In acute study, a single administration of the aqueous extract of Marrubium vulgare was given orally to mice at doses ranging from 2 to 12 g/kg. General behaviour, adverse effects and mortality were determined for up to 14 days post treatment. In the subacute study, the extract was administered orally at doses of 0, 500, 1000, 2000 and 3000 mg/kg daily for 28 days to rats. Animal body weight was observed throughout the experimental period while hematological and biochemical parameters of blood as well as kidney and liver tissues histology were evaluated at the end of the experiment. Results: In the acute study in mice, none of the doses used induced mortality or significant behavioural changes. The sub-acute oral administration of the aqueous extract of Marrubium vulgare caused no noticeable change in the general behaviour of the rats, no significant changes in body weight, food intake and utilization of food in the treated rats. All hematological parameters measured remained within physiological range throughout the treatment period (28 days). Serum AST, ALT, ALP, glucose and triglycerides decreased significantly. Histological analysis did not show any liver or kidney alteration. Conclusion: it may be concluded that the aqueous extract of Marrubium vulgare does not appear to have significant toxicity. In view of the doses consumed empirically in traditional medicine in Morocco, there is a wide margin of safety for the therapeutic use of Marrubium vulgare.

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    Author(s) Name:

    Abdeljalil Rhallaba*, Said Chakira, Khalid Elbadaouia, Taj lmolek Alaouia

    Affiliation(s) Name:

    aLaboratoire de biochimie et de pharmacognosie, Département de biologie, Faculté des Sciences, Université Moulay Ismail, BP 11201 Zitoune, Méknés, Maroc

    *Corresponding author.
    Abdeljalil Rhallab
    Laboratoire de biochimie et de pharmacognosie,
    Département de biologie, Faculté des Sciences,
    Université Moulay Ismail, BP 11201 Zitoune,
    Méknés, Maroc

    Received on:01-05-2014; Revised on: 15-05-2014; Accepted on:20-05-2014

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    Author:

    Abdeljalil Rhallaba*, Said Chakira, Khalid Elbadaouia, Taj lmolek Alaouia

    Title:Evaluation of acute and subacute toxicity of aqueous extracts from Marrubium vulgare L in rodents
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (May)
    Year:2014
    Page No: (684-688)
  • Experimental Methods Keywords

    Methodology:Hematological studies,Biochemical parameters
    Research Materials:Marrubium vulgare

Keywords

Marrubium vulgare Toxicity Hematological studies Biochemical parameters

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