Journal: Drug Invention Today

Article Id: JPRS-PS-00002072
Title: Мellitus diabetes type 2 and congestive heart failure on ambulatory conditions
Category: Pharmacological Screening
Section: Review Article
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    The significance of the problem of congestive heart failure (CHF) is determined by its widespread prevalence, high mortality. The specific gravity of cardiovascular complications in the structure of mortality of patients with mellitus diabetes type 2 is very high. The diabetes mellitus and CHF acquire the status of the epidemic of the 21st century and require health-care costs for the prevention and treatment of these diseases. The using of modern pharmacological drugs and instrumental methods for the treatment of cardiovascular diseases (CVDs) increases life expectancy and improves the quality of life with CHF as with normal carbohydrate metabolism (CM) and with mellitus diabetes type 2 (MD2). However, the risk of cardiovascular mortality in patients with MD2, as compared with those with normal CM remains at the same level. The rapidly growing population of patients with MD2 will soon change the prevailing ideas in recent years to improve the prognosis of CVD treatment. Disturbance of myocardial remodeling with MD2 is due to a combination of factors associated with diabetic cardiomyopathy, a decreasing in the metabolic activity of cardiomyocytes, insufficient transport of glucose into cells, endothelial dysfunction, diabetic macro- and microangiopathy, and myocardial fibrosis by leading to a violation of the left ventricular filling and development of CHF. Insulin resistance (IR) and compensatory hyperinsulinemia (HI) have a key role in the pathogenesis of MD2. To improve the results of treatment aimed at reducing the risk of CHF in patients with MD2 and impaired glucose tolerance (IGT), it is necessary to achieve a traditional primary goal, exactly, glycemic control. Since IR and compensatory HI have a key role in the pathogenesis of MD2 and are closely related to the risk of developing arterial hypertension and CVD caused by atherosclerosis, treatment of patients with MD2 and IGT with CHF requires the using of drugs that affect the IR.

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    Author(s) Name:

    Mаira Barmenbayeva*, Akmaral Abdykulova, Aizhamal Yessirkepova, Aigyul Izhanova

    Affiliation(s) Name:

    Department of Training of General Practitioners, Kazakh National Medical University named after S.D Asfendiyarov, Tole bi Street, 94, Almaty, 140000, Kazakhstan

    *Corresponding author: Mаira Barmenbayeva, Kazakh National Medical University named after S.D Asfendiyarov, Tole bi Street, 94, Almaty, 140000, Kazakhstan.

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    Author:

    Mаira Barmenbayeva*, Akmaral Abdykulova, Aizhamal Yessirkepova, Aigyul Izhanova

    Title:Мellitus diabetes type 2 and congestive heart failure on ambulatory conditions
    Journal:Drug Invention Today
    Vol(issue):10 (Jan)
    Year:2018
    Page No: (80-84)
  • Experimental Methods Keywords

    Methodology: Carbohydrate metabolism, Impaired glucose tolerance, Stroke volume
    Research Materials:Мellitus diabetes type 2, congestive heart failure

Keywords

Carbohydrate metabolism Cardiovascular mortality Congestive heart failure hyperinsulinemia Congestive heart failure Impaired glucose tolerance Stroke volume

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