Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00002077
Title: Functionalized nanoliposomes for the synergistic treatment of rheumatoid arthritis: Monotherapy with quadrilateral approach
Category: Pharmaceutics
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  • Abstract

    Rheumatoid arthritis is a chronic, immune-mediated disease characterized by severe progressive inflammation followed by destruction of joints and related structures. It is an autoimmune disease of unknown causes and a number of information regarding the pathogenesis are still unexplored, thus at present prevention of disease progression is very challenging. Although the treatment has evolved from non-steroidal anti-inflammatory drugs to biological disease-modifying antirheumatic drugs, yet single therapy of any of these drugs is not effective to totally cure the disease and also associated with severe adverse effects. Therefore, to avoid side effects and to make the single therapy more effective and patient friendly, we proposed a hypothesis based on targeted delivery of ligand-appended nanoliposomes of teriflunomide by intravenous route. The proposed nanoliposomes will follow four-pronged synergistic treatment approaches that are targeting through synovial macrophage system uptake, chondroitin sulfate-coated long-circulating effect, CD44 receptor-mediated cellular internalization, and chondroitin sulfate-oriented articular structure regeneration.

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    Author(s) Name:

    Asiya Mahtab1 , Shweta Pandey1 , Syed Arman Rabbani 2 , Mohd. Aqil 1 , SushamaTalegaonkar1,3 *

    Affiliation(s) Name:

    1 Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia, Hamdard, New Delhi, India,

    2 Department of Clinical Pharmacy and Pharmacology, RAK College of Pharmaceutical Sciences, RAK Medical and Health Sciences University Ras Al Khaimah, UAE,

    3 Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, Pushp, Vihar, New Delhi, India

    *Corresponding author: Dr. Sushama Talegaonkar, Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, Pushp Vihar, Sector 3, New Delhi -110017, India.

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    Author:

    Asiya Mahtab1 , Shweta Pandey1 , Syed Arman Rabbani 2 , Mohd. Aqil 1 , SushamaTalegaonkar1,3 *

    Title:Functionalized nanoliposomes for the synergistic treatment of rheumatoid arthritis: Monotherapy with quadrilateral approach
    Journal:Journal of Pharmacy Research
    Vol(issue):12(4)
    Year:2018
    Page No: (589-592)
  • Experimental Methods Keywords

    Methodology:Nanoliposomes,Disease-modifying antirheumatic drugs
    Research Materials:Chondroitin sulfate

Keywords

CD44 Chondroitin sulfate Disease-modifying antirheumatic drugs Lipid nanoparticles Rheumatoid arthritis

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