Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00002078
Title: Anti-inflammatory activity of bioactive flavonoid mesuaferrin-A from Mesua ferrea L. on Lipopolysaccharide-induced pro-inflammatory cytokines in raw 264.7 cells
Category: Pharmacology
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Introduction: Mesuaferrin-A is a bioactive flavonoid isolated from the bark of ethyl extract of Mesua ferrea. L exhibited significant in vitro cyclooxygenase -2/5-LOX dual inhibitory activity. Objective: The present study was designed to investigate the anti-inflammatory activity of Mesuaferrin-A on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Materials and Methods: To evaluate the effect of isolated bioactive flavonoid Mesuaferrin-A on the production of nitric oxide (NO) and pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in the RAW264.7 macrophages by enzyme-linked immunosorbent assay. Results: The Mesuaferrin-A exhibited dose-dependent inhibitory effect on the production of NO and pro-inflammatory cytokines (TNF-α and IL-1β) in LPS-stimulated RAW264 macrophages. Conclusion: From this study, it can be concluded that the isolated bioactive flavonoid Mesuaferrin-A act as potent anti- inflammatory agents, it can be used for the treatment of inflammatory related diseases without having any side effects.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    K. Krishna Chaithanya1 *, V. K. Gopalakrishnan1 , Zenebe Hagos1 , K. Kamalakararao2 , D. Govinda Rao3

    Affiliation(s) Name:

    1 Department of Chemistry, College of Natural and Computational Sciences, Aksum University, Axum, Ethiopia,

    2 Department of Biochemistry, Adikavi Nannaya University, Rajahmundry, Andhra Pradesh, India,

    3 Department of Biochemistry and Molecular Biology, School of Biological Sciences, Central University of Kerala, Kerala, India

    *Corresponding author: Dr. Krishna Chaithanya Karri, Department of Chemistry, College of Natural and Computational Sciences, Aksum University, Axum, Tigray Region, Ethiopia

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    K. Krishna Chaithanya1 *, V. K. Gopalakrishnan1 , Zenebe Hagos1 , K. Kamalakararao2 , D. Govinda Rao3

    Title:Anti-inflammatory activity of bioactive flavonoid mesuaferrin-A from Mesua ferrea L. on Lipopolysaccharide-induced pro-inflammatory cytokines in raw 264.7 cells
    Journal:Journal of Pharmacy Research
    Vol(issue):12(4)
    Year:2018
    Page No: (593-598)
  • Experimental Methods Keywords

    Methodology:Anti-inflammatory agents, Interleukin-1β, Lipopolysaccharides, Mesuaferrin-A, Nitric oxide, Tumor necrosis factor-α
    Research Materials: Mesua ferrea L

Keywords

Anti-inflammatory agents Interleukin-1β Lipopolysaccharides Mesuaferrin-A Nitric oxide Tumor necrosis factor-α

Our Services

Most Downloaded List