Journal: Journal of Pharmacy Research

Article Id: JPRS-PHDRS-00002080
Title: Determination and identification of chemical compounds from ethyl acetate fraction of the stem bark of sintok (Cinnamomum sintoc Bl.)
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
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    Objective: This study aims to isolate and identify the chemical compounds contained in Sintok (Cinnamomum sintoc Bl.) stem bark. Methods: The extraction was performed by maceration method using 70% ethanol solvent and followed by fractionation using n-hexane, ethyl acetate, and water solvent. Ethyl acetate fraction of ethanol extract was further purified using preparative thin-layer chromatography (TLC), using toluene developer:ethyl acetate:Glacial acetic acid (20:40:3) yielded isolate I-P3. Identification was performed on I-P3 using ultraviolet, infrared (IR) spectrophotometers, and gas chromatography–mass spectrometry (GC–MS) methods. Results: The ultraviolet I-P3 spectrum shows the maximum wavelength at 207 nm and 281 nm. The IR spectrum of I-P3 shows the presence of O-H, C-H aliphatic, and C=C aromatic groups. The results of GC–MS show that I-P3 has a retention time of 14 min and has a molecular weight of 220. Conclusion: Based on the data analysis, it is assumed that I-P3 was di-tert-butyl-p-methylphenol.

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    Author(s) Name:

    Yoppi Iskandar1 , Resmi Mustarichie2 *

    Affiliation(s) Name:

    1Department of Biology Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia,

    2 Department Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia.

    *Corresponding author: Resmi Mustarichie, Department Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia.

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    Author:

    Yoppi Iskandar1 , Resmi Mustarichie2 *

    Title:Determination and identification of chemical compounds from ethyl acetate fraction of the stem bark of sintok (Cinnamomum sintoc Bl.)
    Journal:Journal of Pharmacy Research
    Vol(issue):12 (April)
    Year:2018
    Page No: (606-610)
  • Experimental Methods Keywords

    Methodology: Gas chromatography–mass spectrometry, Infrared spectrophotometer
    Research Materials:Bark sintok (Cinnamomum sintoc Bl.)

Keywords

Bark sintok Cinnamomum sintoc Ethyl acetate fraction Gas chromatography–mass spectrometry Infrared spectrophotometer

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