Journal: Journal of Pharmacy Research

Article Id: JPRS-ND-00002084
Title: Identification and characterization of secondary metabolite isolated from the stem bark of Prosopis cineraria (Linn.) Druce and their in vitro anticancer activity against A549 human lung cancer cel
Category: Natural Drugs
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Introduction: The extracts from the stem bark of Prosopis cineraria (Linn.) Druce, “The King of Desert” (Family: Leguminosae and Subfamily: Mimosidae) have been used traditionally as a dietary supplement and as a folk medicine. Its antihyperlipidemic, antioxidative, antimicrobial, anticancer, antihelmintic, analgesic, antitumor, antipyretic, antihypercholesterolemic, nootropic, anticonvulsant activities, and toxicity studies have been reported so far. Materials and Methods: The present study of P. cineraria was evaluated for their extracts, phytochemical screening, and isolation of phytochemicals by column chromatography. The structure of isolated compound (A) was confirmed by spectral studies such as infrared, nuclear magnetic resonance, and mass spectroscopy. The extracts and the isolated compounds were evaluated for their anticancer activity against A549 human lung cancer cell line using Sulforhodamine B-based assay. Results: The phytochemicals screening showed that 50% ethanol extract of the stem bark of P. cineraria contains alkaloids, tannins, saponins, steroids, phenols, terpenoids, and flavonoids. In contrast, aqueous extract of the bark of P. cineraria contains flavonoids only. The 50% ethanolic and aqueous extracts of P. cineraria showed 93.6 µg/ml and 138.6 µg/ml anticancer activities, respectively, against A549 human lung cancer cell line. The isolated compound showed 28.2 µg/ml anticancer activities. Conclusion: It can be concluded that compound isolated from stem bark of P. cineraria had significant anticancer property. The extracts from the stem bark of P. cineraria showed the presences of secondary metabolites which are responsible for the therapeutic effects. Thus, aiming to discover new alternative P. cineraria may be a new hope for the prevention of lung cancer.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    Shweta Kulshrestha, Saima Habib Khan*

    Affiliation(s) Name:

    Department of Chemistry, School of Basic Science, Sam Higginbottom University of Agriculture, Technology and Science, Allahabad, Uttar Pradesh, India

    *Corresponding author: Saima Habib Khan, Department of Chemistry, School of Basic Science, Sam Higginbottom University of Agriculture, Technology and Science, Rewa road, Naini, Allahabad – 211 007, Uttar Pradesh, India.

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Shweta Kulshrestha, Saima Habib Khan*

    Title:Identification and characterization of secondary metabolite isolated from the stem bark of Prosopis cineraria (Linn.) Druce and their in vitro anticancer activity against A549 human lung cancer cel
    Journal:Journal of Pharmacy Research
    Vol(issue):12 (April)
    Year:2018
    Page No: (611-618)
  • Experimental Methods Keywords

    Methodology:A549 human lung cancer cell line, Anticancer activity,
    Research Materials:Prosopis cineraria

Keywords

A549 human lung cancer cell line Anticancer activity Phytochemicals Prosopis cineraria Secondary metabolites

Our Services

Most Downloaded List