Journal: Drug Invention Today

Article Id: JPRS-PS-00002094
Title: Significance of various clinical parameters as early indicators of myocardial infarction - A retrospective study
Category: Pharmacological Screening
Section: Research Article
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    Aim and Objective: This study is to determine the prognostic significance of blood pressure (BP), hemoglobinA1c (HbA1c), blood glucose, and lipid profile assessment and its relation with the cardiac biomarkers in patients who developed myocardial infarction (MI). Materials and Methods: This retrospective study was carried out in a tertiary care hospital from November 2016 to April 2017. Medical records of 185 MI patients for the past 2 years were collected and analyzed. The laboratory parameters such as BP, HbA1c, blood sugar, and lipid profile values were collected from the case sheets 3 months before the occurrence of MI. The cardiac biomarkers such as troponin T, creatine phosphokinase (CPK), and CPK- muscle/ brain (MB) were obtained after the occurrence of MI. The Spearman rank correlation was used to correlate the age, gender, BP, blood sugar, and lipid profile with the cardiac biomarkers. Results: 77.29% of patients were male and 22.71% of patients were female; the average age group of the study population was 57.81 ± 13.82 years. Hypertension was observed in 88% of MI patients. Troponin T and CPK had a significant correlation with diastolic BP (DBP), systolic BP, fasting blood glucose, postprandial blood glucose, glycated hemoglobin (HbA1c), and total cholesterol (TC). CPK-MB had significant correlation only with DBP and body mass index. Conclusion: MI risk was found to be high in diabetic, hypertensive, and dyslipidemic patients. Thus, BP, HbA1c, and TC altogether can be used as a prognostic marker in MI.

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    Author(s) Name:

    T. S. Shanmugarajan1 *, S. Sarumathy2 , K. G. Suresh Rao3 , N. Benazeer Begum2

    Affiliation(s) Name:

    1Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India,

    2 Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India,

    3 Department of Cardiac Anaesthesiologist and Cardiac Critical Care, Fortis Malar Hospital, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. T. S. Shanmugarajan, Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Velan Nagar, P.V.Vaithiyalingam Road, Pallavaram, Chennai – 600 117, Tamil Nadu, India,

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    Author:

    T. S. Shanmugarajan1 *, S. Sarumathy2 , K. G. Suresh Rao3 , N. Benazeer Begum2

    Title:Significance of various clinical parameters as early indicators of myocardial infarction - A retrospective study
    Journal:Drug Invention Today
    Vol(issue):10 (Feb)
    Year:2018
    Page No: (132-136)
  • Experimental Methods Keywords

    Methodology:Medical records of 185 MI patients,collected , analyzed
    Research Materials:Various clinical parameters (Blood pressure, Blood sugar, Lipid profile)

Keywords

Blood pressure Blood sugar Lipid profile Myocardial Infarction Troponin T

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