Journal: Drug Invention Today
Title: Antidiabetic and antihyperlipidemic activities of aqueous and ethanolic leaf extracts of Feronia limonia
Category: Pharmacological Screening
Section: Research Article
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Abstract
Background: Traditional drugs can be used as a novel alternative for synthetic agents. All the synthetic agents possess risk of multiple side effects. Hence, a previously traditionally used drug, Feronia limonia is studied for its antidiabetic and antihyperlipidemic effects. Methods: Ethanolic and aqueous leaf extracts of different concentrations were tested for antidiabetic capabilities on streptozotocin (500 mg/kg I.P)-induced diabetic Swiss albino mice, fasting blood glucose, glycosylated hemoglobin, body weight, lipid profile test, and preliminary phytochemical screening for extracts were also carried out. Results: Significant antidiabetic activity characterized by significant reduction in blood glucose level and glycosylated hemoglobin was observed with ethanolic extract (200 mg/kg) at 14 days of treatment compared with glibenclamide (500 mcg/kg, I.P). Both these extracts showed significant reduction in total cholesterol, triglycerides, and low- density lipoproteins and also on certain liver markers. Conclusion: The study concludes that F. limonia leaf extracts show a significant antidiabetic and antihyperlipidemic activity. Hence, the constituents are isolated for further research.
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Author(s) Name: P. Ranadheer Chowdary1 , D. Praveen1 , A. Niventhi 2 , M. Vijey Aanandhi 3 *
Affiliation(s) Name: 1 School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India,
2 Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India,
3 Research Scholar, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS)
*Corresponding author: Dr. M. Vijey Aanandhi, Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.
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Author: P. Ranadheer Chowdary1 , D. Praveen1 , A. Niventhi 2 , M. Vijey Aanandhi 3 *
Title: Antidiabetic and antihyperlipidemic activities of aqueous and ethanolic leaf extracts of Feronia limonia Journal: Drug Invention Today Vol(issue): 10 (Feb) Year: 2018 Page No: (0-0) -
Experimental Methods Keywords
Methodology: Antidiabetic, Antihyperlipidemic activity Research Materials: Feronia limonia
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