Journal: Drug Invention Today

Article Id: JPRS-PS-00002103
Title: Free radical scavenging of 4-benzylpiperidine by in vitro method
Category: Pharmacological Screening
Section: Research Article
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    Aim and Objective: The purpose of the study is to screen the free radical scavenging of 4-benzylpiperidine using the various in vitro method. Materials and Methods: In this research, various concentration of 4-benzylpiperidine was screened for in vitro antioxidant activity such as 1-diphenyl-2-picrylhydrazyl radical (DPPH) assay, nitric oxide scavenging activity, hydroxyl radical scavenging assay, reducing power assessment, and total antioxidant capacity (TAC). Results and Discussion: Our study results show that 4-benzylpiperidine produced significant P < 0.05 inhibition in scavenging the free radicals when compared with the standard (ascorbic acid and curcumin) in DPPH, nitric oxide, hydroxyl radical scavenging assay, and exhibited maximum percentage scavenging of 89.24, 88.05, and 68.49 at 1 mg/ml, respectively. 4-benzylpiperidine also showed a significant increase in absorbance with an increase in concentration in reducing power assay. TAC result was found to be not significant but have maximum absorbance than standard which is expressed as a number of equivalents to Vitamin C. Conclusion: We conclude that 4-benzylpiperidine have potential antioxidant property and equipotent to the standard used. It may be potent and novel therapeutic agents for scavenging of radicals and regulate the pathological conditions of various diseases caused by excessive generation of free radical.

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    Author(s) Name:

    D. Richard Daniel, K. Manjuladevi*, V. Jayashree, V. Deepak, Azzeezah Begum Habeb

    Affiliation(s) Name:

    Department of Pharmacology, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India

    *Corresponding author: K. Manjuladevi, Department of Pharmacology, School of Pharmaceutical sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai - 600 117, Tamil Nadu, India.

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    Author:

    D. Richard Daniel, K. Manjuladevi*, V. Jayashree, V. Deepak, Azzeezah Begum Habeb

    Title:Free radical scavenging of 4-benzylpiperidine by in vitro method
    Journal:Drug Invention Today
    Vol(issue):10 (Feb)
    Year:2018
    Page No: (179-184)
  • Experimental Methods Keywords

    Methodology:1-diphenyl-2-picrylhydrazyl radical, Total antioxidant capacity, Antioxidant activity
    Research Materials:4-benzylpiperidine

Keywords

4-benzylpiperidine 1-diphenyl-2-picrylhydrazyl radical Total antioxidant capacity Antioxidant activity

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