Journal: Drug Invention Today

Article Id: JPRS-pp-00002104
Title: A prospective study on the efficacy of levetiracetam in seizure patients
Category: Pharmacy Practice
Section: Research Article
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    Aim and Objectives: The aim of the study was to determine the efficacy of levetiracetam (LEV) in seizure patients and to compared between the monotherapy and polytherapy. Materials and Methods: The entire study was planned to be carried out for a period of 6 months. The selected study population was 60 patients. A separate data entry form for incorporating patient details was designed. The collected data were analyzed using Microsoft Excel and GraphPad Prism Software. The unpaired t-test and ANOVA were used to compare, and the significant difference was determined. Results and Discussion: Out of the 60 number of patients in the study, 53% were male, and 47% were female. Majority of patients in the age group of 15–25 were affected with seizures. The major cause for epilepsy in our study is head trauma (33%). The seizure frequency at the end of the last month of the visit was noted, and it was compared with the baseline seizure frequency for patients with generalized tonic-clonic seizures (GTCS), complex partial seizures (CPS), and for secondarily generalized seizure patients. The number of seizure episodes in the final visit was less as compared with those in the 1st month before the treatment with LEV. Conclusion: LEV was effective as monotherapy and polytherapy for all the three categories of patients-GTCS, CPS, and secondarily generalized seizures. The baseline seizure frequency, when compared with the final visit frequency, has improved after the treatment with LEV.

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    Author(s) Name:

    P. Maheshwari*, N. Moulindhar Reddy, N. Sonia, G. Kasturi, M. Sriram, P. Shanmugasundaram

    Affiliation(s) Name:

    Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, India

    *Corresponding author: P. Maheshwari, Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Velannagar, P.V. Vaithiyalingam Road, Pallavaram, Chennai - 600 117, Tamil Nadu, India

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    Author:

    P. Maheshwari*, N. Moulindhar Reddy, N. Sonia, G. Kasturi, M. Sriram, P. Shanmugasundaram

    Title:A prospective study on the efficacy of levetiracetam in seizure patients
    Journal:Drug Invention Today
    Vol(issue):10 (Feb)
    Year:2018
    Page No: (185-188)
  • Experimental Methods Keywords

    Methodology:60 patients, Complex partial seizures, Generalized tonic-clonic seizures, Monotherapy, Polytherapy
    Research Materials:Levetiracetam

Keywords

Complex partial seizures Generalized tonic-clonic seizures Monotherapy Polytherapy

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