Journal: Drug Invention Today

Article Id: JPRS-TE-00002106
Title: Toxicity evaluation of ifosfamide nanostructured lipid carriers designed for oral delivery in Wistar albino rats
Category: Toxicity evaluation
Section: Research Article
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    Aim: Ifosfamide nephrotoxicity is a serious adverse effect for one who undergoes cancer chemotherapy. Ifosfamide when administered orally as nanoparticles expected to minimize the ifosfamide‑induced nephrotoxicity at a clinically relevant concentration. To further validate this expectation, an animal model of ifosfamide‑induced nephrotoxicity was used to determine the protective effect of ifosfamide‑loaded nanostructured lipid carriers when administered orally. Materials and Methods: Adult male and female Wistar albino rats were subjected to acute and subacute toxicity studies administering orally with ifosfamide‑loaded nanostructured lipid carrier. Wister albino rats of either sex were administered with 0.5 ml of the vehicle, ifosfamide injection at a dose of 50 mg/kg body weight, and ifosfamide NLC orally at doses of 50 and 100 mg/kg body weight. Toxic manifestations and mortality were monitored daily. Both the serum and urine biochemical parameters and hematological parameters were determined using standardized laboratory method. Results: There was no mortality, or any signs of behavioral changes or toxicity observed after oral administration of ifosfamide NLC up to the dose level of 150 mg/kg body weight in rats. Ifosfamide NLCs, when administered orally, markedly reduce the severity of renal dysfunction induced by ifosfamide with a significant decrease in elevations of serum creatinine (47.82 ± 2.25 vs. 32.64 ± 1.28 mmol l − 1 ) as well as a reduced elevation of β2‑microglobulin excretion (25.54 ± 122 vs. 19.86 ± 1.22 nmol l − 1 ) and magnesium excretion (19.62 ± 1.56 vs. 16.12 ± 1.22 mmol l − 1 ). Conclusion: Our results suggest a potential therapeutic role for ifosfamide when administered as nanoparticle minimizing ifosfamide nephrotoxicity

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    Author(s) Name:

    Ramaiyan Velmurugan*, Keerthi G. S. Nair

    Affiliation(s) Name:

    Department of Pharmacology, School of Pharmaceutical Sciences, Vels Institute of Sciences, Technology and Advanced Studies, Chennai, Tamil Nadu, India

    *Corresponding author: Ramaiyan Velmurugan, Department of Pharmacology, School of Pharmaceutical Sciences, Vels Institute of Sciences, Technology and Advanced Studies, Chennai ‑ 600 117, Tamil Nadu, India.

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    Author:

    Ramaiyan Velmurugan*, Keerthi G. S. Nair

    Title:Toxicity evaluation of ifosfamide nanostructured lipid carriers designed for oral delivery in Wistar albino rats
    Journal:Drug Invention Today
    Vol(issue):10 (Feb)
    Year:2018
    Page No: (192-196)
  • Experimental Methods Keywords

    Methodology:Oral delivery, Acute and subacute toxicity,Nanostructured lipid carrier, Nephrotoxicity
    Research Materials: Ifosamide

Keywords

Oral delivery Acute and subacute toxicity Ifosamide Nanostructured lipid carrier Nephrotoxicity

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