Journal: Drug Invention Today

Article Id: JPRS-pp-00002110
Title: Metformin-induced lactic acidosis: A review
Category: Pharmacy Practice
Section: Review Article
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    Metformin is an oral anti-diabetic drug that is widely used alone or in combination with other drugs with type 2 diabetes mellitus. Metformin increases insulin sensitivity, enhances peripheral glucose utilization and decreases glucose uptake in the gastrointestinal tract. Lactic acidosis is characterized by the buildup of lactate (especially L-lactate) in the body, which results in an excessively low pH in the bloodstream. Lactic acidosis is about 20 times less frequent with metformin than phenformin. Lactate is produced by the gut, liver, and peripheral tissues during glycolysis and can accumulate during hypoxic conditions. Lactate can either be oxidized to carbon dioxide and water by mitochondria to generate energy or converted back to glucose (gluconeogenesis) in the liver and kidney. When metformin is administered orally, approximately 40% of the dose is absorbed. Metformin-associated lactic acidosis is more likely to occur in patients who acutely develop renal impairment from dehydration, vomiting or diarrhea, surgery, etc., especially in elderly subjects who have a reduced glomerular filtration rate.

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    Author(s) Name:

    V. P. Derbin Vijay1 , D. Praveen2 , P. Ranadheer Chowdary2 , M. Vijey Aanandhi 3 *

    Affiliation(s) Name:

    1 Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India, 2 Research Scholar, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India, 3 Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India *Corresponding Zauthor: Dr. M. Vijey Aanandhi, Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.

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    Author:

    V. P. Derbin Vijay1 , D. Praveen2 , P. Ranadheer Chowdary2 , M. Vijey Aanandhi 3 *

    Title:Metformin-induced lactic acidosis: A review
    Journal:Drug Invention Today
    Vol(issue):10 (Feb)
    Year:2018
    Page No: (216-218)
  • Experimental Methods Keywords

    Methodology:Diabetes, Lactic acidosis
    Research Materials:Metformin

Keywords

Diabetes Lactic acidosis Metformin

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