Journal: Drug Invention Today

Article Id: JPRS-pp-00002111
Title: Proton pump inhibitor-induced hypomagnesemia - A review
Category: Pharmacy Practice
Section: Review Article
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    Proton pump inhibitors (PPI) are the most commonly prescribed drugs for prevention and treatment of acid-related diseases. Hypomagnesemia has been recommended as one of the rare effects of the long-term use of PPIs. Hypomagnesemia occurs as a result of impaired magnesium absorption in the intestine. Prolonged hypomagnesemia can result in various systemic defects such as cardiac arrhythmias, tetany, seizures, and electrolytic imbalances such as hypocalcemia and hypokalemia. Magnesium supplement administration provides temporary relief and withdrawal or intermittent use of PPI on long-term therapy (≥1 year) can reduce hypomagnesemia. Monitoring the serum Mg2+ routinely on long-term therapy helps to prevent the occurrence of hypomagnesemia to a great extent.

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    Author(s) Name:

    U. Sanvas1 , D. Praveen2 , P. Ranadheer Chowdary2 , M. Vijey Aanandhi 3 *

    Affiliation(s) Name:

    1 Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Chennai, Tamil Nadu, India,

    2 Research Scholar, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies (VISTAS),

    3 Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Chennai, Tamil Nadu, India

    *Corresponding author: Dr.M. Vijey Aanandhi, Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Chennai, Tamil Nadu India.

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    Author:

    U. Sanvas1 , D. Praveen2 , P. Ranadheer Chowdary2 , M. Vijey Aanandhi 3 *

    Title:Proton pump inhibitor-induced hypomagnesemia - A review
    Journal:Drug Invention Today
    Vol(issue):10 (Feb)
    Year:2018
    Page No: (219-221)
  • Experimental Methods Keywords

    Methodology:Hypomagnesemia, Peptic ulcer,
    Research Materials:Proton pump inhibitors (PPI)

Keywords

Hypomagnesemia Peptic ulcer Proton pump inhibitors

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