Journal: Drug Invention Today

Article Id: JPRS-pp-00002113
Title: A review on drug-induced nephrotoxicity
Category: Pharmacy Practice
Section: Review Article
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    Drug-induced nephrotoxicity (DIN), which is the toxicity in the kidneys, accounts for up to 60% of hospital-acquired acute kidney injury with considerable morbidity and mortality. Nephrotoxicity displays symptoms such as decreased urine output, fluid retention, fatigue, and nausea. One of the chemotherapeutic agents, cisplatin, is used to treat cancer in numerous treatments, and cisplatin-induced nephrotoxicity is a common side effect, affecting cancer treatment. Several other drugs such as methotrexate, vancomycin, calcineurin inhibitors, amphotericin B, and aminoglycosides may also lead to nephrotoxicity. Anticancer drugs cause high toxicity leading kidney dysfunction and irreparable kidney injury. Risk for kidney injury is increased by increase in dose and duration of potentially nephrotoxic drugs. Identification of DIN and rapid dose reduction of the offending agents are critical to maximize kidney function recovery.

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    Author(s) Name:

    Richa Prakash1 , D. Pavithra1 , D. Praveen2 , P. Ranadheer Chowdary2 , M. Vijey Aanandhi 3

    Affiliation(s) Name:

    1 Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Chennai, Tamil Nadu, India,

    2 Research Scholar, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies (VISTAS),

    3 Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. M. Vijey Aanandhi, Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Advanced Studies and Science and Technology, Chennai, Tamil Nadu, India.

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    Author:

    Richa Prakash1 , D. Pavithra1 , D. Praveen2 , P. Ranadheer Chowdary2 , M. Vijey Aanandhi 3

    Title:A review on drug-induced nephrotoxicity
    Journal:Drug Invention Today
    Vol(issue):10 (Feb)
    Year:2018
    Page No: (225-227)
  • Experimental Methods Keywords

    Methodology:Nephrotoxicity, Pathophysiology
    Research Materials: Antibiotics

Keywords

Adverse drug reaction Antibiotics Anticancer drugs Nephrotoxicity Pathophysiology

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