Journal: Drug Invention Today

Article Id: JPRS-PS-00002121
Title: Screening methods for antihyperlipidemic activity: A review
Category: Pharmacological Screening
Section: Review Article
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    Hyperlipidemia is characterized by increased level of cholesterol in the form of low-density lipoprotein (LDL), chylomicrons, very LDL (VLDL), etc. Development of new antihyperlipidemic drugs is a challenging job of researchers because most of the screening procedures are tedious and time-consuming. The present techniques for screening methods for antihyperlipidemic activity could be classified under in vitro and in vivo methods. The in vivo methods include Triton-, PTU-, and high-fat diet- induced hyperlipidemic models. In contrast, the reported in vitro methods are limited and include assay using Caco-2 cell lines and inhibitory activity on 3-Hydroxy-3-methylglutaryl-coenzyme A reductase. There is a lack of simple but sufficiently reproducible and sensitive in vitro technique for screening of antihyperlipidemic activity.

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    Author(s) Name:

    U. S. Jijith1,2, S. Jayakumari 1 *

    Affiliation(s) Name:

    1 Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, India,

    2 College of Pharmaceutical Sciences is a department of Government Medical College

    *Corresponding author: Dr. S. Jayakumari, Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Velan Nagar, Pallavaram, Chennai – 600 117.

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    Author:

    U. S. Jijith1,2, S. Jayakumari 1 *

    Title:Screening methods for antihyperlipidemic activity: A review
    Journal:Drug Invention Today
    Vol(issue):10 (Feb)
    Year:2018
    Page No: (257-259)
  • Experimental Methods Keywords

    Methodology:Antihyperlipidemic activity
    Research Materials:Screening methods

Keywords

Caco-2 cells 3-Hydroxy-3-methylglutaryl-coenzyme A reductase NADPH Propylthiouracil Thincert plate Triton

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