Journal: Drug Invention Today

Article Id: JPRS-D(DD)-00002122
Title: Evaluation of in vitro rheumatoid arthritis activity of polyherbal ethanolic extract containing formulations for selected potential Indian herbs
Category: Drug (Discovery/Development)
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    Objective: Arthritis has emerged to be a very common disorder affecting statistically one-third of the population. The present study aims to investigate the effectiveness of a polyherbal formulation Polygonum glabrum, Canthium dicoccum, Ochna obtusata, and Argyreia nervosa in treating the disorder arthritis. Materials and Methods: Ethanolic extract of different portions are used to investigate by in vitro inhibition of protein denaturation method using bovine serum, inhibition of protein denaturation method using egg albumin, and human red blood cell (HRBC) membrane stabilization method. Results: The result revealed that the formulations F2 and F4 possessed significant anti-arthritic activity by protein denaturation inhibition and HRBC membrane stabilization comparing with diclofenac sodium, the standard drug used. Conclusion: The study concluded that the above two formulations are an effective inhibitor of protein denaturation and HRBC membrane stabilization which can be used potent anti-arthritic activity.

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    Author(s) Name:

    V. Satyanarayana, S. Jaya Kumari*

    Affiliation(s) Name:

    Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. S. Jaya Kumari, Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Velan Nagar, Pallavaram, Chennai - 60011, Tamil Nadu, India.

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    Author:

    V. Satyanarayana, S. Jaya Kumari*

    Title:Evaluation of in vitro rheumatoid arthritis activity of polyherbal ethanolic extract containing formulations for selected potential Indian herbs
    Journal:Drug Invention Today
    Vol(issue):10(3)
    Year:2018
    Page No: (260-265)
  • Experimental Methods Keywords

    Methodology: in vitro rheumatoid arthritis activity
    Research Materials:Argyreia nervosa, Canthium dicoccum, Ochna obtusata, Polygonum glabrum, Polyherbal

Keywords

Argyreia nervosa Canthium dicoccum Ethanolic extract In vitro rheumatoid Ochna obtusata Polygonum glabrum Polyherbal

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