Journal: Drug Invention Today

Article Id: JPRS-D(DD)-00002126
Title: Formulation and evaluation of hesperidin-loaded chitosan nanosuspension for brain targeting
Category: Drug (Discovery/Development)
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    Aim: Parkinson’s disease is characterized by a progressive loss of dopaminergic neuron in the substantia nigra. Hesperidin is a free radical scavenger that has been shown to have a protective effect against oxidative insults. An antioxidant can neutralize the free radical by accepting or donating an electron to eliminate the unpaired condition. Materials and Methods: Hesperidin- loaded chitosan nanosuspension was prepared by ionic gelation method using tripolyphosphate and chitosan. There was no incompatibility observed between the drug and polymer through Fourier-transform infrared and differential scanning calorimetric. Various other parameters such as particle size, zeta potential, scanning electron microscope, drug content, drug entrapment efficiency, and in vitro release have been utilized for the characterization of nanoparticles. Results and Discussion: The average particle size of 188 nm, zeta potential of 48.7 mV, drug content of 0.470 ± 0.25 mg/ml, and entrapment efficiency of 78.2% are obtained with HPN3 formulation. The HPN1 shows the highest drug release followed by HPN2 due to the low concentration of polymer, and HPN4 and HPN5 show less drug release due to the high concentration of polymer. The in vitro release of HPN3 85.2% showed an initial burst release of approximately 60% in the 1st 8 h, followed by a slow and much reduced additional release for about 24 h. Conclusion: HPN3 was chosen as the best formulation due to its reduced particle size and controlled release at optimum polymer concentration which may be taken for the effective treatment of Parkinson’s disease.

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    Author(s) Name:

    I. Somasundaram*, S. Sumathi, S. P. Bhuvaneshwari, K. Mohammed Shafiq, T. S. Shanmugarajan

    Affiliation(s) Name:

    Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.

    *Corresponding author: I. Somasundaram, Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies Pallavaram, Chennai - 600 117, Tamil Nadu, India.

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    Author:

    I. Somasundaram*, S. Sumathi, S. P. Bhuvaneshwari, K. Mohammed Shafiq, T. S. Shanmugarajan

    Title:Formulation and evaluation of hesperidin-loaded chitosan nanosuspension for brain targeting
    Journal:Drug Invention Today
    Vol(issue):10 (March)
    Year:2018
    Page No: (279-284)
  • Experimental Methods Keywords

    Methodology:Nanoparticles, Parkinson’s disease, Reactive oxygen species
    Research Materials:Chitosan, Hesperidin

Keywords

Chitosan Hesperidin Nanoparticles Parkinson’s disease Reactive oxygen species

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