Journal: Drug Invention Today

Article Id: JPRS-D(DD)-00002127
Title: A review on applications of natural polymers in gastroretentive drug delivery system
Category: Drug (Discovery/Development)
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    The objective of this review is to provide the overview of the role of natural polymers in gastroretentive drug delivery system (GRDDS), its characteristics, ongoing research, trend of future developments, and applications in the field. Appropriate articles were searched from Medline database using the search term “Natural Polymer and Gastric,” restricted search for the past 5 years and accessed only 21 open access articles to narrate this review. The approach of various natural polymers in industrial applications such as medicine, agriculture, and similar areas is growing rapidly in this era. It was observed biodegradable and non-toxic materials like the natural polymers are evident by the mounting level of its use in the pharmaceutical field. Using various natural polymers have been aiding the drug delivery systems for prolongation of time as the drug transporters with the objective of improving bioavailability and therapeutic efficacy. The use of natural polymers in novel drug delivery like GRDDS to possess floating or mucoadhesive in the gastric system for the benefit of increasing gastric resident time and to improve therapeutic efficacy, particularly those drugs are having narrow therapeutic index such as carvedilol, itopride, and glipizide. The physical characteristics of natural polymers facilitates sustained, swelling, and mucoadhesive nature based on literature reviewed, therefore, natural polymers also suitable to GRDDS as like synthetic or semi-synthetic polymers.

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    Author(s) Name:

    R. Ananthakumar1 *, K. Chitra2 , S. Satheshkumar1

    Affiliation(s) Name:

    1 Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, India,

    2 Department of Pharmaceutical Chemistry, Sri Ramachandra Medical College & Research Institute (DU), Chennai, Tamil Nadu, India

    *Corresponding author: R. Ananthakumar, Department of Pharmaceutics, Vels Institute of Science, Technology and Advanced Studies, School of Pharmaceutical Sciences, P.V.Vaithiyalingam road, Pallavaram, Chennai – 600 117, Tamil Nadu, India.

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    Author:

    R. Ananthakumar1 *, K. Chitra2 , S. Satheshkumar1

    Title:A review on applications of natural polymers in gastroretentive drug delivery system
    Journal:Drug Invention Today
    Vol(issue):10(3)
    Year:2018
    Page No: (285-289)
  • Experimental Methods Keywords

    Methodology:Drug delivery, Gastroretentive drug delivery system
    Research Materials:Natural polymers

Keywords

Drug delivery Gastric Herbal Mucoadhesive Polymers

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