Journal: Drug Invention Today

Article Id: JPRS-DRP-00002135
Title: Challenges in delivery of chemotherapeutic agents for the treatment of brain cancer and the scope of nanoparticulates
Category: Drug Release Profiles
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    Brain tumor remains one of the most dreadful, poorly prognosed cancer despite advances in understanding the molecular basis of carcinogenesis. Treatment of brain tumors requires a multidisciplinary approach that includes combination of surgery, radiation, or chemotherapy. The major hindrance to prognosis of brain tumor is the autoprotective nature of the brain and blood–brain barrier (BBB). The approaches involves deliberate opening of the tight junctions of the BBB or delivery of drugs “through” or “behind” BBB by manipulating the physicochemical properties of the drug and have major drawbacks including irreversible opening of BBB that potentially allows the entry of exogenous material such as viruses and bacteria, and allows limited spatial distribution of drug. Nanoparticles (NPs) focus on the administration of nanometric size particles loaded with chemotherapeutic agent, monoclonal antibodies, genes, proteins, peptides, and other entities. Due to its small size and modifiability warrant their selective uptake by the tumor cells. They can be formulated out of variety of substance and can carry multiple loads of drugs directing the substance toward the tumor cells. Thus in comparison to conventional therapies, NPs reduces the side effects. Number of drug delivery strategies has been developed to overcome challenges presented by the BBB. One technique that holds promise for bypassing the BBB to deliver drugs to the brain the spillover effect of drug to normal tissue is intranasal delivery. The intranasal delivery of NP loaded anticancer drug provides a practical and noninvasive method for delivering therapeutic agents to the brain due to the unique anatomical connections.

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    Author(s) Name:

    Sadhu Venkateswara Rao, S. Sathesh Kumar*

    Affiliation(s) Name:

    Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India

    *Corresponding author: S. Sathesh Kumar, Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai - 600 117, Tamil Nadu, India.

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    Author:

    Sadhu Venkateswara Rao, S. Sathesh Kumar*

    Title:Challenges in delivery of chemotherapeutic agents for the treatment of brain cancer and the scope of nanoparticulates
    Journal:Drug Invention Today
    Vol(issue):10(3)
    Year:2018
    Page No: (330-342)
  • Experimental Methods Keywords

    Methodology:Blood–brain barrier, Cancer, Nanoparticles,
    Research Materials:Chemotherapeutic agents

Keywords

Blood–brain barrier Cancer Nanoparticles Targeting

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