Journal: Drug Invention Today

Article Id: JPRS-PS-00002140
Title: Analgesic and anti-inflammatory activities of Dichrostachys cinerea (L.) Wight and Arn.
Category: Pharmacological Screening
Section: Research Article
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    Background: Dichrostachys cinerea (Family - Mimosaceae), known as “Viddathalai” in Tamil, is well-known plant used in the traditional system of medicines such as Ayurveda and Siddha. The traditional plant is commonly used by tribal of India and South Africa. The plant is claimed to possess more therapeutic medicinal uses such as anti-inflammatory, analgesic, antipyretic also used in rheumatism, urinary calculi, and in diarrhea, which is evident from traditional knowledge. Methods: Based on the literature review, the proposed study is intended to validate scientifically the folklore claims for its analgesic, anti-inflammatory, and antioxidant activity. Therein, an attempt has been made for screening the various inflammation-associated activities as per standard protocols to prove its efficacy on support of folklore uses. Results: Qualitative phytochemical analysis of leaf, stem bark, and root revealed that petroleum ether extract showed the presence of terpenoid and steroid. Chloroform extract has shown the presence of glycosides, the alcoholic extract showed the presence of tannin, flavonoids, and phenolic compounds. Aqueous extract showed positive test for saponin and tannins. The acute toxicity study of ethanolic extract of D. cinerea leaf (EDCL), ethanolic extract of D. cinerea bark (EDCB), and ethanolic extract of D. cinerea root (EDCR) carried out revealed that all the extracts were not toxic up to 2000 mg/kg. Hence, the tested extracts were found to be within the safe margin. The results of the different parameter carried out for 28 days in subacute toxicity studies of EDCL, EDCB, and EDCR did not reveal any toxic effect in the two dose levels tested by biochemical and histopathological examination and have wide safety margin. The test extracts, namely, leaf, stem bark, and root extract were found to show significant analgesic activity in both centrally and peripherally mediated analgesia. Anti-inflammatory screening indicates that stem bark, leaf, and root were effective in acute model, whereas stem bark is ineffective in chronic model. The results of antioxidant activity act as a prelude for anti-inflammatory study and these are attributed to the presence of phytoconstituents tested in our extracts. Conclusion: The data retrieved from the observations have been formulated into a diagnostic protocol of Dichrostachys cinerea. The promising biological activities will definitely lead to develop a new drug from the plant and also form the foundation for a future research work in bioactivity-guided isolation of active principles.

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    E. Susithra*, S. Jayakumari

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    E. Susithra*, S. Jayakumari

    Title:Analgesic and anti-inflammatory activities of Dichrostachys cinerea (L.) Wight and Arn.
    Journal:Drug Invention Today
    Vol(issue):10 (March)
    Page No: (361-366)
  • Experimental Methods Keywords

    Methodology:Analgesic, Anti-inflammatory, Antioxidant activity,Toxicity
    Research Materials:Bark, Dichrostachys cinerea, Leaf, Root


Analgesic Anti-inflammatory Antioxidant activity Bark Dichrostachys cinerea Leaf Root Toxicity

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