Journal: Drug Invention Today

Article Id: JPRS-BSN-00002141
Title: Application of phytochemicals for the treatment of neurodegenerative diseases
Category: Biomaterials ( Synthetic and Natural )
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Neurodegeneration is defined as the progressive loss of structure or function of neurons which includes amyotrophic sclerosis, Alzheimer’s disease, and Huntington’s disease. Many neurodegenerative diseases are caused by genetic mutations; however, multiple biological processes can cause neurodegeneration. Synthetic drugs are widely used for the treatment of most neurodegenerative disorders which are reported to cause side effects during the treatment. Researchers identified some naturally occurring chemical compounds in plants, i.e., phytochemical through various research programs, and these are used for the management of neurodegenerative diseases. Phytochemicals are generally accepted to be safe with minimal side effects. In this review, we comprehensively compiled the plant-derived compounds such as polyphenol, isothiocyanate, alkaloid, and cannabinoid, and other important phytochemicals reported possess beneficial effect in neurodegenerative disorders. These phytochemical compounds have various effects such as neuroprotective, antioxidant, and anti-inflammatory actions. In the case of phytochemical studies, different plants and plant parts containing many valuable constituents such as lignans, flavonoids, tannins, triterpenes, and sterols, and these constituents are exhibit neuroregeneration or neuroprotective effect. Many Ayurvedic formulations prepared from various plants are claimed to possess neurostimulant activity, thus improving the symptomatic conditions in patients with neurodegenerative disorders. The folklore medicine has also possessed a significant contribution identifying neurotonic and nerve stimulants. The systematic ethanopharmacological studies had yielded highly reliable results in exploring the phytochemical agents for the treatment of neurodegenerative disorders. This review article will provide the researchers comprehensive information about the plants and the mechanisms elucidated by them through in vivo or in vitro studies.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    Kailash Kumar N, Greeshma John S, S. Sathesh Kumar*

    Affiliation(s) Name:

    Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Pallavaram, Chennai, Tamil Nadu, India

    *Corresponding author: S. Sathesh Kumar, Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Pallavaram, Chennai, Tamil Nadu, India.

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Kailash Kumar N, Greeshma John S, S. Sathesh Kumar*

    Title:Application of phytochemicals for the treatment of neurodegenerative diseases
    Journal:Drug Invention Today
    Vol(issue):10(3)
    Year:2018
    Page No: (367-372)
  • Experimental Methods Keywords

    Methodology:Neurodegenerative disorders, Neurotonic agents,
    Research Materials:Phytochemical agents

Keywords

Neurodegenerative disorders Neurotonic agents Phytochemical agents

Our Services

Most Downloaded List