Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002142
Title: A review on the role of estrogen, estrogen receptor and signaling pathways in breast carcinogenesis
Category: Pharmacology
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Estrogens were one of the primary female sex hormones, and it plays an important role in both reproductive and non-reproductive systems. It can also be synthesized in non-reproductive tissue as liver, heart, muscle, bone, and brain. The estradiol (E2) was considered to be a major estrogen hormone which is involved in the progression of breast cancer, and a majority of the human breast cancers start out as estrogen dependent and express the estrogen receptor (ER). Interruption of ER function mainly (ER)-α in breast cancer is an effective therapeutic strategy. HOXB13, IL17BR, and CHDH are estrogen-regulated genes where their prognostic utility is likely to impact on their regulation through both ER- and HER2-dependent pathways. Genomic and extranuclear signaling pathways are the main two estrogen signaling pathway where estradiol acts on the ER. In the genomic pathway, estradiol (E2) binds to ER-α and relocalizes estrogen to estrogen-responsive elements and promotes target genes expression. In the extranuclear signaling pathways, rapid E2 signaling activates PI3K/Akt/mTOR and eRK/mitogen-activating protein kinase pathway. Thus, estrogen signal regulates cell proliferation, apoptosis, and cell cycle, following control cell or tissue growth.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    V. Jayashree*, Malarkodi Velraj

    Affiliation(s) Name:

    Department of Pharmacology, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Pallavaram, Chennai, Tamil Nadu, India

    *Corresponding author: V. Jayashree, Department of Pharmacology, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Pallavaram, Chennai, Tamil Nadu, India.

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    V. Jayashree*, Malarkodi Velraj

    Title:A review on the role of estrogen, estrogen receptor and signaling pathways in breast carcinogenesis
    Journal:Drug Invention Today
    Vol(issue):10(3)
    Year:2018
    Page No: (373-376)
  • Experimental Methods Keywords

    Methodology:Genomic and extranuclear signaling pathway
    Research Materials:Estrogens

Keywords

Estradiol Estrogen Estrogen receptor Genomic and extranuclear signaling pathway

Our Services

Most Downloaded List