Journal: Drug Invention Today

Article Id: JPRS-D(DD)-00002143
Title: Docetaxel-loaded chitosan nanoparticles to enhance the chemotherapeutic efficacy in lung cancer
Category: Drug (Discovery/Development)
Section: Research Article
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    Purpose: The purpose of the research is to prepare an optimized chitosan nanoparticle for Docetaxel. Method: Docetaxel- loaded chitosan nanoparticles were prepared by water in oil emulsion cross-linking method. Response surface methodology using the Box–Behnken design was used to optimize the formulations of docetaxel-loaded chitosan nanoparticles. Results: The drug entrapment efficiency, drug loading efficiency, particle size, and zeta potential of docetaxel-loaded chitosan nanoparticles were 93.10%, 8.17%, 100 nm, and −24.17 mV, respectively. Transmission electron microscope of the optimized nanoparticles showed spherical particles. Furthermore, docetaxel-loaded chitosan nanoparticles displayed the highest cytotoxicity against lung cancer cells. The result indicated that the docetaxel nanoparticle had sustained release efficacy. The results indicated that the nanoparticles could deliver docetaxel mainly to lung after iv. injection to mice and the concentration of docetaxel in lung (781.4 ng/g, 0.25 h) was significantly higher than those in other tissue and plasma. Conclusion: The nanoparticle formulation demonstrated a promising perspective for the targeted delivery of docetaxel for lung cancer.

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    Author(s) Name:

    Keerthi G. S. Nair1 *, Ramaiyan Velmurugan2

    Affiliation(s) Name:

    1 Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Sciences, Technology and Advanced Studies, Chennai, Tamil Nadu, India,

    2 Department of Pharmacology, School of Pharmaceutical Sciences, Vels Institute of Sciences, Technology and Advanced Studies, Chennai, Tamil Nadu, India

    *Corresponding author: Keerthi G. S. Nair, Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Sciences, Technology and Advanced Studies, Chennai - 600 117, Tamil Nadu, India.

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    Author:

    Keerthi G. S. Nair1 *, Ramaiyan Velmurugan2

    Title:Docetaxel-loaded chitosan nanoparticles to enhance the chemotherapeutic efficacy in lung cancer
    Journal:Drug Invention Today
    Vol(issue):10 (March)
    Year:2018
    Page No: (377-386)
  • Experimental Methods Keywords

    Methodology:Box–Behnken design, Chitosan nanoparticles,Lung cancer, Target delivery
    Research Materials: Docetaxel

Keywords

Box–Behnken design Chitosan nanoparticles Docetaxel Lung cancer Target delivery

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