Journal: Journal of Pharmacy Research

Article Id: JPRS-PA-00002149
Title: Simultaneous spectrophotometric determination of azithromycin and levofloxacin from solid dosage form
Category: Pharmaceutical Analysis
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    Aim: Simple, precise, and economical spectrophotometric methods have been developed for the simultaneous estimation of azithromycin (AZI) and levofloxacin (LFI) in tablet formulations. Methods: The first method is based on the use of multicomponent mode analysis, the second method is based on the absorbance ratio of the components, that is, absorbance ratio method, and the third is partial least squares calibration method. Results: The proposed methods do not require any prior chemical separation for their estimation from the dosage form. The Beer’s law range was varying from 20–100 µg/ml in Methods I and II and 2–10 µg/ml for method III for both the drugs AZI and LFI. Conclusion: All three proposed methods were successfully applied to the determination of AZI and LFI in several synthetic and real sample matrices.

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    Author(s) Name:

    Lakshmi Sivasubramanian1 *, D. Balanagamani 1 , R. Mamatha2

    Affiliation(s) Name:

    1 Department of Pharmaceutical Analysis, Sri Venkateswara College of Pharmacy, RVS Nagar, Tirupathi Road, Chittoor, Andhra Pradesh, India,

    2 Department of Pharmaceutical Analysis, Bharat Institute of Technology, Mangalpally Village, Ibrahimpatnam, Hyderabad, Telangana, India

    *Corresponding author: Lakshmi Sivasubramanian, Department of Pharmaceutical Analysis, Sri Venkateswara College of Pharmacy, RVS Nagar, Tirupathi Road, Chittoor, Andhra Pradesh, India.

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    Author:

    Lakshmi Sivasubramanian1 *, D. Balanagamani 1 , R. Mamatha2

    Title:Simultaneous spectrophotometric determination of azithromycin and levofloxacin from solid dosage form
    Journal:Journal of Pharmacy Research
    Vol(issue):12(5)
    Year:2018
    Page No: (679-683)
  • Experimental Methods Keywords

    Methodology: Simultaneous spectrophotometric determination ,Multicomponent analysis, Partial least squares regression,Absorbance ratio method,
    Research Materials:Azithromycin, Levofloxacin

Keywords

Absorbance ratio method Azithromycin Levofloxacin Multicomponent analysis Partial least squares regression

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