Journal: Drug Invention Today

Article Id: JPRS-Other-00002163
Title: Fabrication and evaluation of polylactic acid membrane for drug delivery system
Category: Others ( DIT Related Science )
Section: Research Article
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    Background: Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. There are some common ways of drug delivery system that are oral, sublingual, rectal, urogenital, nasal, ophthal, transmucosal, parenteral, and inhalation. Aim: The aim of this study is the fabrication and evaluation of polylactic acid (PLA) membrane for newer drug releasing system. Materials and Methods: PLA (0.5 g, 1.0 g, and 1.5 g) was dissolved in n-methyl pyrrolidone and 50 mg of oxacillin was added to each of these solutions. The PLA solutions containing oxacillin were transferred to 3 Petri dishes, and the solvent was evaporated by keeping the samples in a hot air oven at a temperature of 60°C. The drug release was estimated using ultraviolet spectrophotometer at 24 h intervals at a wavelength of 365. Results: During the 1st h, there exists a burst effect, which may be due to drug lying beneath the surface of the membrane dissolving faster than drug crystals embedded in the center of the spheres, and for every 24 h, the drug released from the membrane has been calculated. Conclusion: Here, the bulk of drug was entrapped within the membrane. Hence, more porous PLA forms such as sponges, microspheres, and electrospun fibers would need to be explored as suitable carriers for drug delivery system.

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    Author(s) Name:

    G. Sweetha1 , Abby Abraham1 , M. Dhanraj 2 , Ashish R. Jain2*

    Affiliation(s) Name:

    1 Department of Prosthodontics and Implant Dentistry, Saveetha Dental College, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. Ashish R. Jain, Department of Prosthodontics, Saveetha Dental College and Hospital, Saveetha University, Ponamalle High Road, Chennai – 600 127, Tamil Nadu, India.

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    Author:

    G. Sweetha1 , Abby Abraham1 , M. Dhanraj 2 , Ashish R. Jain2*

    Title:Fabrication and evaluation of polylactic acid membrane for drug delivery system
    Journal:Drug Invention Today
    Vol(issue):10 (April)
    Year:2018
    Page No: (433-436)
  • Experimental Methods Keywords

    Methodology:ultraviolet spectrophotometer, Fabrication and evaluation
    Research Materials:Biomaterials

Keywords

Biomaterials Drug Membrane Polylactic acid Polymer

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