Journal: Drug Invention Today

Article Id: JPRS-BRPT-00002165
Title: In vitro anticancer activity of extract fractions resulted from fermented endophytic fungi on Taxus sumatrana
Category: Biotechnology & Related Pharmaceutical Technology
Section: Editorial
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    Objectives: This study aims to determine the effects of anticancer, the effective concentration of extract fractions, and which type of bacteria produce the best activity in inhibiting the growth of T47D cancer cells. Methods: A total of seven endophytic bacteria isolated from Taxus sumatrana plant. Each bacterium was fermented and then extracted using three different solvents, i.e., n-hexane, ethyl acetate, and butanol. These extracts tested its anticancer activity using T47D cell line with cisplatin as a positive control. Results: It was found that not all fermented extracts of bacterial endophytic plants T. sumatrana were able to inhibit the growth of T47D cancer cells. The active extracts were n-hexane extracts from the bacterium TsC1, ethyl acetate extract from the bacterium TsC2, n-hexane extract from the bacterium TsC3, butanol extract from the bacterium TsC4, n-hexane extract from the bacterium TsC5, ethyl acetate extract from the bacteria, and extract of ethyl acetate and butanol extract from bacterium TsC7. The results obtained were statistically tested using a Random Complete Block Design with a 95% confidence level. Conclusions: The best effective extract, when compared with cisplatin, is the fraction of ethyl acetate and butanol from the bacterium TsC7.

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    Author(s) Name:

    Resmi Mustarichie1 *, Linar Zalinar Udin2

    Affiliation(s) Name:

    1 Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia,

    2 Department of Chemistry, Research Centre for Chemistry, LIPI, Serpong, Indonesia

    *Corresponding author: Resmi Mustarichie, Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia.

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    Author:

    Resmi Mustarichie1 *, Linar Zalinar Udin2

    Title:In vitro anticancer activity of extract fractions resulted from fermented endophytic fungi on Taxus sumatrana
    Journal:Drug Invention Today
    Vol(issue):10 (April)
    Year:2018
    Page No: (443-449)
  • Experimental Methods Keywords

    Methodology:In vitro anticancer activity
    Research Materials:Endophytic bacteria, Taxus sumatrana

Keywords

Anticancer Endophytic bacteria Fermentation Taxus sumatrana

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