Journal: Drug Invention Today

Article Id: JPRS-D(DD)-00002171
Title: Co-Administration of D Serine with Sodium Benzoate attenuates Ketamine Neurodegeneration in IMR 32 cell lines
Category: Drug (Discovery/Development)
Section: Research Article
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    Ketamine is a commonly used veterinary anesthetic agent and it is abused since it is a recreational agent. It is being reported that ketamine-induced neurodegeneration is a common syndrome in ketamine abusing individuals. This drug being an NMDA (N-methyl-D-aspartate) receptor antagonist it causes the hypofunction in the receptor causing learning and memory impairment. The mechanism underlying in the ketamine-induced neurodegeneration was due to the formation of ketamine metabolite that actively decreases the D serine levels in the brain leading to neurodegeneration. Hence, the study was carried out to study the effect of D-serine and D-serine and sodium benzoate administration attenuated the neurodegeneration induced by ketamine. In the cell study, it was found that ketamine causes neurodegeneration in a dose-dependent manner. The dose-dependent effect of ketamine was attenuated using D-Serine and D-Serine and sodium benzoate concurrent administration.

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    Author(s) Name:

    S. Nithya, T. S. Shanmugarajan*

    Affiliation(s) Name:

    Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, India

    *Corresponding author: T. S. Shanmugarajan, Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies, Pallavaram, Chennai - 600 117, Tamil Nadu, India.

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    Author:

    S. Nithya, T. S. Shanmugarajan*

    Title:Co-Administration of D Serine with Sodium Benzoate attenuates Ketamine Neurodegeneration in IMR 32 cell lines
    Journal:Drug Invention Today
    Vol(issue):10 (April)
    Year:2018
    Page No: (475-478)
  • Experimental Methods Keywords

    Methodology:In Vitro Assay for Cell Viability Activity,Lactate Dehydrogenase (LDH) Release
    Research Materials:D-Serine, Ketamine

Keywords

Anaesthetic D-Serine Ketamine Neurodegeneration Sodium benzoate

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