Journal: Journal of Pharmacy Research

Article Id: JPRS-PSPA-00002189
Title: Phytochemical investigation and in vitro antimalarial activities of stem barks of Campylospermum zenkeri and roots of Campylospermum vogelii
Category: Phytochemical Study and Pharmacological Activity
Section: Research Article
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  • Abstract

    Objective: The objective of this study is to isolate phytochemicals and to determine the antimalarial activities of methanol extracts of the roots of Campylospermum vogelii and stem bark of Campylospermum zenkeri. Materials and Methods: The present study was performed to reveal phytochemical profile of C. vogelii and C. Zenkeri using various chromatographic as well as spectroscopic techniques. The antimalarial activity of the isolated compounds and extracts was evaluated using CQR, 7G8 and Dd2 strains of the human malaria parasite Plasmodium falciparum in a parasite lactate dehydrogenase assay and Sybr green I-based assay. Results: From the phytochemical study of methanol extract of C. zenkeri, a new procyanidin B3 derivative named dihydrozenkerinol was isolated along with four known biflavonoids. Meanwhile, from the methanol extract of roots of C. vogelii, eight known compounds were isolated. The in vitro antimalarial activity of methanol extract of C. zenkeri showed significant activity compared to C. vogelii with inhibitory concentration (IC50 ) = 50 µg/mL against Dd2 strain of P. falciparum. The most potent phytochemicals were campylospermine (10) an amide alkaloid, which had an IC50 of 5.91 µg/mL against CQR, 7G8. Moreover, at a concentration of 100 μg/mL, in vitro, 3 tested compounds (zenkerinol, ß-D-fructofuranosyl-α-D-glucopyranoside, and stigmasterol) inhibited 70% or more of the parasite growth of Dd2 strain. Conclusion: The species from Campylospermum genus are mainly a promising potential source of antiplasmodial compounds, specifically through its phytoconstituents belonging to alkaloid and biflavonoid classes. These results emphasize the role of traditional medicinal plants in the research and development of antimalarial phytopharmaceuticals.

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    Author(s) Name:

    Norbert Mbabi Nyemeck II1,2 , Dominique Serge Ngono Bikobo1* , Auguste Abouem A Zintchem1,3 , Patrick Hervé Betote Diboué4 , Bruno Lenta Ndjakou3 , Dieudonné Emmanuel Pegnyemb1 and Ulrich Koert 2

    Affiliation(s) Name:

    1 Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon,

    2 Department of Chemistry, Philipps-Universität Marburg, Hans-Meerwein Strasse, 35032 Marburg, Germany,

    3 Department of Chemistry, Higher Training College, University of Yaoundé I, Yaoundé, Cameroon,

    4 Department of Microbiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.

    *Corresponding author: Dr. Dominique Serge Ngono Bikobo, Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O Box 812, Yaoundé, Cameroon

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    Author:

    Norbert Mbabi Nyemeck II1,2 , Dominique Serge Ngono Bikobo1* , Auguste Abouem A Zintchem1,3 , Patrick Hervé Betote Diboué4 , Bruno Lenta Ndjakou3 , Dieudonné Emmanuel Pegnyemb1 and Ulrich Koert 2

    Title:Phytochemical investigation and in vitro antimalarial activities of stem barks of Campylospermum zenkeri and roots of Campylospermum vogelii
    Journal:Journal of Pharmacy Research
    Vol(issue):12 (May)
    Year:2018
    Page No: (689-696)
  • Experimental Methods Keywords

    Methodology:CQR, dihydrozenkerinol, Nuclear magnetic resonance,spectroscopic techniques
    Research Materials:Campylospermine, Campylospermum vogelii, Campylospermum zenkeri,

Keywords

Campylospermine Campylospermum vogelii Campylospermum zenkeri CQR dihydrozenkerinol Nuclear magnetic resonance Ochnaceae Plasmodium falciparum

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